Gerald Kerkut Charitable Trust - Publications
(Last update: March 2023)

October 1997

Fiona Oakley

Current role: Professor of Fibrosis Biology at the University of Newcastle on Tyne

Thesis title: Histidine stimulated trace element uptake into human erythrocytes, HEL cells and HEL total RNA injected Xenopus laevis oocytes (2000)

Horn NM, Thomas AL & Oakley F. (2003). Trace Metal Transport. In Red Cell Membrane Transport in Health and Disease, ed. Bernhardt I & Ellory JC, pp. 435-450. Springer Berlin Heidelberg, Berlin, Heidelberg.
https://link.springer.com/chapter/10.1007/978-3-662-05181-8_17

Oakley F, Horn NM & Thomas AL. (2004). Histidine-stimulated divalent metal uptake in human erythrocytes and in the erythroleukaemic cell line HEL.92.1.7. J Physiol 561, 525-534.
http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2004.072389/abstract

Oakley F, Trim N, Constandinou CM, Ye W, Gray AM, Frantz G, Hillan K, Kendall T, Benyon RC, Mann DA & Iredale JP. (2003). Hepatocytes express nerve growth factor during liver injury: evidence for paracrine regulation of hepatic stellate cell apoptosis. Am J Pathol 163, 1849-1858.
https://www.ncbi.nlm.nih.gov/pubmed/14578185

Horn NM, Oakley F, & Thomas, AL (1998)
Histidine stimulated metal uptake into human erythrocytes.
Journal of Physiology (London) 513, 50P

Oakley F, Horn NM, Hubbard A, & Thomas, AL (1998)
The effects of heavy metals on histidine-stimulated ⁶⁵Zn uptake into human erythrocytes.
Journal of Physiology (London) 511, 38P

Oakley F, Mann J, Ruddell RG, Pickford J, Weinmaster G & Mann DA. (2003). Basal Expression of IκBα Is Controlled by the Mammalian Transcriptional Repressor RBP-J (CBF1) and Its Activator Notch1. Journal of Biological Chemistry 278, 24359-24370.
http://www.jbc.org/citmgr?gca=jbc%3B278%2F27%2F24359

October 2001

Neil Ravenhill

Current role: Medical Director at Synergy Medical (as of 2018)

Thesis title: The biochemistry of serpin secretion: an investigation into the effects of mutant and corrective variants.  (2004)

Parfrey H, Mahadeva R, Ravenhill NA, Zhou A, Dafforn TR, Foreman RC & Lomas DA. (2003). Targeting a surface cavity of alpha 1-antitrypsin to prevent conformational disease. J Biol Chem 278, 33060-33066.
https://www.ncbi.nlm.nih.gov/pubmed/12807889

October 2004

Neil Hopper (Postdoctoral Rearcher)

Holden-Dye L, O'Connor V, Hopper NA, Walker RJ, Harder A, Bull K, & Guest, M (2007)
SLO, SLO, quick quick slow: calcium-activated potassium channels as regulators of Caenorhabditis elegans behaviour and targets for antihelmintics. Invertebrate Neuroscience 7: 199-208

Paula Costello

Current role: Institute of Developmental Sciences, University of Southampton, (as of 2018)

Thesis title: The effect of maternal nutrition, & body condition on the structure, & function of skeletal muscle in the offspring

Costello PM, Cripps RL, Bearpark N, Rowlerson A, Hollis L, Patel H, Aihie Sayer A, Hanson MA, Ozanne SE, & Green LR (2008)
Effect of maternal diet and body condition on glucose metabolism and skeletal muscle structure in mature adult sheep offspring.
The Physiological Society 2008 Main Meeting, Cambridge, Proc Physiol Soc 11, C32

Costello PM, Rowlerson A, Astaman NA, Anthony FEW, Aihie Sayer A, Cooper C, Hanson MA, & Green, LR (2008)
Per-implantation and late gestation maternal undernutrition differentially affect fetal sheep skeletal muscle development.
Journal of Physiology 586, 2371-2379

Costello PM, Hollis LI, Cripps Rl, Bearpark N, Patel HP, Sayer AA, Cooper C, Hanson MA, Ozanne SE & Green LR. (2013). Lower maternal body condition during pregnancy affects skeletal muscle structure and glut-4 protein levels but not glucose tolerance in mature adult sheep. Reprod Sci 20, 1144-1155
https://www.ncbi.nlm.nih.gov/pubmed/23420826

Costello PM, Rowlerson A, Braddick L, Burrage D, Cooper C, Hanson MA, Aihie Sayer A, & Green LR (2006)
Fetal skeletal muscle fibre number and type are altered by early and late gestation maternal undernutrition in sheep.
Proceedings of the Physiological Society 3 C116

Costello PM, Astaman NA, Anthony FW, Aihie Sayer A, Cooper C, Hanson MA, & Green, LR (2007)
Peri-implantation and late gestation undernutrition differentially alter pathways of insulin and IGF-1 action in fetal sheep.
The 5th International Congress on DOHaD (2007), University of Western Australia.
Early Human Development 83, S135 (P2-23)

Costello PM, Rowlerson A, Braddick L, Burrage D, Cooper C, Aihie Sayer A, Hanson MA, & Green LR (2007)
Fetal muscle capillary density is reduced by both early and late gestation maternal undernutrition in sheep.
The Physiological Society Focussed Meeting (Perinatal Physiology: from uterus to brain), University of Edinburgh.
Proc Physiol Soc 6, PC2

Costello PM, Torrens C, Braddick L, Burrage D, Hanson MA, & Green, LR
Circulating glucose affects vascular reactivity in the late gestation sheep.
The 4th World Congress on DOHaD, University of Utrecht, The Netherlands
Early Human Development 82, 518-519 (C-07)

Costello PM, Rowlerson A, Astaman NA, Anthony FE, Sayer AA, Cooper C, Hanson MA & Green LR. (2008). Peri-implantation and late gestation maternal undernutrition differentially affect fetal sheep skeletal muscle development. J Physiol 586, 2371-2379.
https://www.ncbi.nlm.nih.gov/pubmed/18339691

Burrage DM, Braddick L, Cleal JK, Costello P, Noakes DE, Hanson MA & Green LR. (2009). The late gestation fetal cardiovascular response to hypoglycaemia is modified by prior peri-implantation undernutrition in sheep. J Physiol 587, 611-624.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670084/

October 2005

Sarah Young

Current role: Clinical Research Facilitator at Great Ormond Street Hospital (as of 2018)

Thesis title: The effect of diet on food preferences, & life history traits in Drosophila melanogaster

Cally Gill

Current role: Postdoctoral research, Division of Women's Health. St Thomas' Hospital, London (as of 2018)

Thesis title: Proteomic analysis of interstitial fluid for novel markers of the cutaneous response to injury
https://eprints.soton.ac.uk/72793/

Stenken JA, Church MK, Gill CA & Clough GF. (2010). How minimally invasive is microdialysis sampling? A cautionary note for cytokine collection in human skin and other clinical studies. AAPS J 12, 73-78.
https://link.springer.com/article/10.1208%2Fs12248-009-9163-7

Gill C, Parkinson E, Church MK, Skipp P, Scott D, White AJ, O'Connor CD & Clough GF. (2011). A qualitative and quantitative proteomic study of human microdialysate and the cutaneous response to injury. AAPS J 13, 309-317.
https://link.springer.com/article/10.1208%2Fs12248-011-9269-6

L'Esperance VS, Cox SE, Simpson D, Gill C, Makani J, Soka D, Mgaya J, Kirkham FJ & Clough GF. (2013). Peripheral vascular response to inspiratory breath hold in paediatric homozygous sickle cell disease. Exp Physiol 98, 49-56.
https://www.ncbi.nlm.nih.gov/pubmed/22660812

He DW, Nguyen HC, Hayes-Gill BR, Zhu YQ, Crowe JA, Gill C, Clough GF & Morgan SP. (2013). Laser Doppler Blood Flow Imaging Using a CMOS Imaging Sensor with On-Chip Signal Processing. Sensors-Basel 13, 12632-12647.
https://www.ncbi.nlm.nih.gov/pubmed?term=Cally%20Gill%5BAuthor%5D

Daniel Asby

Current role: Research Associate, Clinical Neuroscience, University of Bristol (as of 2018)

Thesis title: Modelling androgen synthesis and action during human sexual differentiation 
https://eprints.soton.ac.uk/400340/

Asby DJ, Arlt W & Hanley NA. (2009). The adrenal cortex and sexual differentiation during early human development. Rev Endocr Metab Disord 10, 43-49.
https://www.ncbi.nlm.nih.gov/pubmed/18670886

Asby DJ, Radigois MG, Wilson DC, Cuda F, Chai CL, Chen A, Bienemann AS, Light ME, Harrowven DC & Tavassoli A. (2016). Triggering apoptosis in cancer cells with an analogue of cribrostatin 6 that elevates intracellular ROS. Org Biomol Chem 14, 9322-9330.
http://pubs.rsc.org/en/Content/ArticleLanding/2016/OB/C6OB01591C#!divAbstract

Asby DJ, Cuda F, Beyaert M, Houghton FD, Cagampang FR & Tavassoli A. (2015). AMPK Activation via Modulation of De Novo Purine Biosynthesis with an Inhibitor of ATIC Homodimerization. Chem Biol 22, 838-848.
http://www.sciencedirect.com/science/article/pii/S1074552115002343?via%3Dihub

Bartlett N, Gross L, Peron F, Asby DJ, Selby MD, Tavassoli A & Linclau B. (2014). Stereocontrol by quaternary centres: a stereoselective synthesis of (-)-luminacin D. Chemistry 20, 3306-3310.
http://onlinelibrary.wiley.com/doi/10.1002/chem.201304776/abstract

Asby DJ, Cuda F, Hoakwie F, Miranda E & Tavassoli A. (2014). HIF-1 promotes the expression of its alpha-subunit via an epigenetically regulated transactivation loop. Mol Biosyst 10, 2505-2508.
http://pubs.rsc.org/en/Content/ArticleLanding/2014/MB/C4MB00351A#!divAbstract

Shmma Quraishe

Current role: BBSRC Research Fellow, Biological Sciences, Southampton (as of 2018)

Thesis title: The sHsp expression signature in the brain and modulation in models of chronic neurodegeneration
https://eprints.soton.ac.uk/160233/

Garland P, Quraishe S, French P & O'Connor V. (2008). Expression of the MAST family of serine/threonine kinases. Brain Res 1195, 12-19.
http://www.sciencedirect.com/science/article/pii/S0006899307030156?via%3Dihub

Cowan CM, Sealey MA, Quraishe S, Targett MT, Marcellus K, Allan D & Mudher A. (2011). Modelling tauopathies in Drosophila: insights from the fruit fly. Int J Alzheimers Dis 2011, 598157.
https://www.hindawi.com/journals/ijad/2011/598157/cta/

Cowan Catherine M, Quraishe S & Mudher A. (2012). What is the pathological significance of tau oligomers? Biochemical Society Transactions 40, 693.
http://www.biochemsoctrans.org/content/40/4/693

Garland P, Broom LJ, Quraishe S, Dalton PD, Skipp P, Newman TA & Perry VH. (2012). Soluble axoplasm enriched from injured CNS axons reveals the early modulation of the actin cytoskeleton. PLoS One 7, e47552.
http://journals.plos.org/plosone/article/citation?id=10.1371/journal.pone.0047552

Quraishe S, Cowan CM & Mudher A. (2013). NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy. Mol Psychiatry 18, 834-842.
https://www.nature.com/mp/journal/v18/n7/full/mp201332a.html

Quraishe S, Asuni A, Boelens WC, O'Connor V & Wyttenbach A(2008)
Expression of the small heat shock protein family in the mouse CNS: Differentiation anatomical and biochemical compartmentilization.
Neuroscience. 153, 483-491

Sinadinos C, Quraishe S, Sealey M, Samson PB, Mudher A & Wyttenbach A. (2013). Low endogenous and chemical induced heat shock protein induction in a 0N3Rtau-expressing Drosophila larval model of Alzheimer's disease. J Alzheimers Dis 33, 1117-1133.
https://www.ncbi.nlm.nih.gov/pubmed/23114515

Rebecca Holloway

Current role: Research Associate, Airway Disease, Imperial College London (as of 2018)

Thesis title: The role of elastase as an inflammatory stimulus in chronic obstructive pulmonary disease 2010
https://eprints.soton.ac.uk/162673/1/Rebecca_Holloway_thesis_1_.pdf

Hackett TL, Holloway R, Holgate ST & Warner JA. (2008). Dynamics of pro-inflammatory and anti-inflammatory cytokine release during acute inflammation in chronic obstructive pulmonary disease: an ex vivo study. Respir Res 9, 47.
https://www.ncbi.nlm.nih.gov/pubmed/18510721

Nicholson GC, Holloway RA, Leaker BR, Kilty I, Salganik M, Tan L, Barnes PJ & Donnelly LE. (2016). A novel flow cytometric-based method to measure kinase inhibition in sputum from COPD subjects. BMJ Open Respir Res 3, e000140.
http://bmjopenrespres.bmj.com/content/3/1/e000140

Holloway RA & Donnelly LE. (2013). Immunopathogenesis of chronic obstructive pulmonary disease. Curr Opin Pulm Med 19, 95-102.
https://www.ncbi.nlm.nih.gov/pubmed/23325031

Cassie Richardson

Current role: Lecturer in Psychology, University of Central Lancashire (as of 2018)

Thesis title: Awareness in Ageing
https://eprints.soton.ac.uk/66450/1/C_Richardson_PhD_DEFINITIVE.pdf

Cormack F, Shipolini A, Awad WI, Richardson C, McCormack DJ, Colleoni L, Underwood M, Baldeweg T & Hogan AM. (2012). A meta-analysis of cognitive outcome following coronary artery bypass graft surgery. Neuroscience and biobehavioral reviews 36, 2118-2129.
https://www.ncbi.nlm.nih.gov/pubmed/22732162

Richardson C, Hogan AM, Bucks RS, Baya A, Virues-Ortega J, Holloway JW, Rose-Zerilli M, Palmer LJ, Webster RJ, Kirkham FJ & Baldeweg T. (2011). Neurophysiological evidence for cognitive and brain functional adaptation in adolescents living at high altitude. Clin Neurophysiol 122, 1726-1734.
https://www.ncbi.nlm.nih.gov/pubmed/21377415

Richardson C, Bucks RS & Hogan AM. (2011). Effects of aging on habituation to novelty: an ERP study. International journal of psychophysiology : official journal of the International Organization of Psychophysiology 79, 97-105.
https://www.ncbi.nlm.nih.gov/pubmed/20869996

October 2006

Catherine Forristal

Current role: Stem Cell Biology Group, Mater Medical Research Institute, Brisbane, Australia

Thesis title: Hypoxic regulation of Human embryonic stem cells

E Forristal C, L Wright K, A Hanley N, Oreffo R & Houghton F. (2009). Hypoxia inducible factors regulate pluripotency and proliferation in human embryonic stem cells cultured at reduced oxygen tensions, vol. 139.
https://www.researchgate.net/publication/26813328_Hypoxia_inducible_factors_regulate_pluripotency_and_proliferation_in_human_embryonic_stem_cells_cultured_at_reduced_oxygen_tensions

Forristal CE, Nowlan B, Barbier V, Winkler I, Walkinshaw G & Lévesque J-P. (2012). FG-4497, a pharmacological stabilizer of HIF-1alpha protein, synergistically enhances hematopoietic stem cells (HSC) mobilization in response to G-CSF and plerixafor, vol. 120.
https://www.researchgate.net/publication/284609906_FG-4497_a_pharmacological_stabilizer_of_HIF1alpha_protein_synergistically_enhances_hematopoietic_stem_cells_HSC_mobilization_in_response_to_G-CSF_and_plerixafor

Winkler I, Pettit A, J Raggatt L, Jacobsen R, E Forristal C, Barbier V, Nowlan B, Cisterne A, J Bendall L, Sims N & Lévesque J-P. (2012). Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation, vol. 26.
https://www.researchgate.net/publication/221767999_Hematopoietic_stem_cell_mobilizing_agents_GCSF_cyclophosphamide_or_AMD3100_have_distinct_mechanisms_of_action_on_bone_marrow_HSC_niches_and_bone_formation

Winkler I, J Bendall L, E Forristal C, M Helwani F, Nowlan B, Barbier V, Shen Y, Cisterne A, Sedger L & Lévesque J-P. (2012). B-lymphopoiesis is stopped by mobilizing doses of G-CSF and is rescued by overexpression of the anti-apoptotic protein Bcl2, vol. 98.
https://www.researchgate.net/publication/230756041_B-lymphopoiesis_is_stopped_by_mobilizing_doses_of_GCSF_and_is_rescued_by_overexpression_of_the_anti-apoptotic_protein_Bcl2

Winkler I, Barbier V, Nowlan B, Jacobsen R, E Forristal C, T Patton J, Magnani J & Lévesque J-P. (2012). Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance, vol. 18.
https://www.researchgate.net/publication/232533792_Vascular_niche_Eselectin_regulates_hematopoietic_stem_cell_dormancy_self_renewal_and_chemoresistance

E. Forristal C, Winkler I, Nowlan B, Barbier V, Walkinshaw G & Lévesque J-P. (2013). Pharmacologic stabilization of HIF-1 alpha increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation, vol. 121.
https://www.researchgate.net/publication/235363458_Pharmacologic_stabilization_of_HIF-1_alpha_increases_hematopoietic_stem_cell_quiescence_in_vivo_and_accelerates_blood_recovery_after_severe_irradiation

E. Forristal C, Christensen D, E. Chinnery F, Petruzzelli R, L. Parry K, Sanchez-Elsner T & Houghton F. (2013). Environmental Oxygen Tension Regulates the Energy Metabolism and Self-Renewal of Human Embryonic Stem Cells, vol. 8.
https://www.researchgate.net/publication/236684899_Environmental_Oxygen_Tension_Regulates_the_Energy_Metabolism_and_Self-Renewal_of_Human_Embryonic_Stem_Cells

Forristal C, Helwani F, Nowlan B, Martin S, Zannetino A & Lévesque J-P. (2013). Hypoxia inducible factor (HIF)-2α enhances proliferation of malignant haematopoietic cells in the hypoxic malignant bone marrow, vol. 41.
https://www.researchgate.net/publication/288274848_Hypoxia_inducible_factor_HIF-2a_enhances_proliferation_of_malignant_haematopoietic_cells_in_the_hypoxic_malignant_bone_marrow

Forristal C, Nowlan B, Barbier V, Winkler I, Walkinshaw G & Lévesque J-P. (2013). Pharmacological stabilization of hypoxia-inducible factor-1α (HIF-1α) enhances hematopoietic stem cell mobilization in response to G-CSF and plerixafor, vol. 41.
https://www.researchgate.net/publication/273431248_Pharmacological_stabilization_of_hypoxia-inducible_factor-1a_HIF-1a_enhances_hematopoietic_stem_cell_mobilization_in_response_to_G-CSF_and_plerixafor

E Forristal C & Lévesque J-P. (2013). Targeting the Hypoxia-Sensing Pathway in Clinical Hematology, vol. 3.
https://www.researchgate.net/publication/259474144_Targeting_the_Hypoxia Sensing_Pathway_in_Clinical_Hematology

Jacobsen R, E Forristal C, J Raggatt L, Nowlan B, Barbier V, Kaur S, Van Rooijen N, Winkler I, Pettit A & Lévesque J-P. (2014). Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80+VCAM1+CD169+ER-HR3+Ly6G+ erythroid island macrophages in the mouse, vol. 42.
https://www.researchgate.net/publication/261602362_Mobilization_with_granulocyte_colony-stimulating_factor_blocks_medullar_erythropoiesis_by_depleting_F480VCAM1CD169ER-HR3Ly6G_erythroid_island_macrophages_in_the_mouse

E Forristal C, Nowlan B, Jacobsen R, Barbier V, Walkinshaw G, R Walkley C, Winkler I & Lévesque J-P. (2015). HIF-1 is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1, vol. 29.
https://www.researchgate.net/publication/270910880_HIF-1_is_required_for_hematopoietic_stem_cell_mobilization_and_4-prolyl_hydroxylase_inhibitors_enhance_mobilization_by_stabilizing_HIF-1

E Forristal C, Brown A, M Helwani F, Winkler I, Nowlan B, Barbier V, Powell J, A Engler G, Diakiw S, Zannettino A, Martin S, Pattabiraman D, D'Andrea J, D Lewis I & Lévesque J-P. (2015). Hypoxia Inducible Factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML.
https://www.researchgate.net/publication/275644616_Hypoxia_Inducible_Factor_HIF-2a_accelerates_disease_progression_in_mouse_models_of_leukemia_and_lymphoma_but_is_not_a_poor_prognosis_factor_in_human_AML

Ayse Ismail

Current role: medical editor for the Oman Medical Journal (as of 2018)

Thesis title: Interactions between human embryonic stem cell and foetal femur derived cell populations - development of strategies for tissue regeneration 
https://eprints.soton.ac.uk/375470/

Nik Rogers

Current role: Finance Director GSK (as of 2018)

Thesis title: The structure of a voltage gated potassium channel https://eprints.soton.ac.uk/187983/1/Thesis_-_Nik_Rogers.pdf

Sylvia Gaspar Pereira

Thesis title: The role of NF-κB1 in heart physiology, & disease (2008) University of Newcastle on Tyne

Pereira SG & Oakley F. (2008). Nuclear factor-kappaB1: regulation and function. Int J Biochem Cell Biol 40, 1425-1430.
http://www.sciencedirect.com/science/article/pii/S1357272507001501

Gaspar-Pereira S, Fullard N, Townsend PA, Banks PS, Ellis EL, Fox C, Maxwell AG, Murphy LB, Kirk A, Bauer R, Caamano JH, Figg N, Foo RS, Mann J, Mann DA & Oakley F. (2012). The NF-kappaB subunit c-Rel stimulates cardiac hypertrophy and fibrosis. Am J Pathol 180, 929-939.
https://www.ncbi.nlm.nih.gov/pubmed/22210479

Whyte CS, Bishop ET, Ruckerl D, Gaspar-Pereira S, Barker RN, Allen JE, Rees AJ & Wilson HM. (2011). Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function. J Leukocyte Biol 90, 845-854.
https://www.ncbi.nlm.nih.gov/pubmed/21628332

Simone Holley

Current role: Research Psychologist, Adolescent Asthma study, University of Southampton (as of 2018)

Thesis title: Sleep and neuropsychological functioning in school aged children https://eprints.soton.ac.uk/71784/1/Holley_thesis.pdf

Holley S, Hill CM & Stevenson J. (2010). A comparison of actigraphy and parental report of sleep habits in typically developing children aged 6 to 11 years. Behav Sleep Med 8, 16-27.
http://www.tandfonline.com/doi/abs/10.1080/15402000903425462?lipi=urn%3Ali%3Apage%3Ad_flagship3_profile_view_base%3BmNGS5jK6TeWuTFnseN6HXQ%3D%3D&

Annaz D, Hill CM, Ashworth A, Holley S & Karmiloff-Smith A. (2011). Characterisation of sleep problems in children with Williams syndrome. Res Dev Disabil 32, 164-169.
http://www.sciencedirect.com/science/article/pii/S0891422210002040?lipi=urn%3Ali%3Apage%3Ad_flagship3_profile_view_base%3BmNGS5jK6TeWuTFnseN6HXQ%3D%3D

Holley S, Hill CM & Stevenson J. (2011). An hour less sleep is a risk factor for childhood conduct problems. Child Care Health Dev 37, 563-570.
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2214.2010.01203.x/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=&lipi=urn:li:page:d_flagship3_profile_view_base&mNGS5jK6TeWuTFnseN6HXQ

Wayte S, McCaughey E, Holley S, Annaz D & Hill CM. (2012). Sleep problems in children with cerebral palsy and their relationship with maternal sleep and depression. Acta Paediatr 101, 618-623.
http://onlinelibrary.wiley.com/doi/10.1111/j.1651-2227.2012.02603.x/abstract?userIsAuthenticated=false&deniedAccessCustomisedMessage=&lipi=urn:li:page:d_flagship3_profile_view_base&mNGS5jK6TeWuTFnseN6HXQ

October 2007

Aneta Rybka

Davidson SM, Rybka AE & Townsend PA. (2009). The powerful cardioprotective effects of urocortin and the corticotropin releasing hormone (CRH) family. Biochem Pharmacol 77, 141-150.
https://www.ncbi.nlm.nih.gov/pubmed/18817752

Angela Cheung

Current role: Career Development Fellow, Francis Crick Institute, Mill Hill London (as of 2018)

Thesis title: Nitric oxide mediates the neuroproliferative effect of Neuropeptide Y (2012)
https://eprints.soton.ac.uk/338969/1/PHD_THESIS_Angela_Cheung.pdf

Cheung A, Newland P, Zaben M, S Attard G & Gray W. (2012). Intracellular Nitric Oxide Mediates Neuroproliferative Effect of Neuropeptide Y on Postnatal Hippocampal Precursor Cells, vol. 287.
https://www.ncbi.nlm.nih.gov/pubmed/22474320

Gray WP & Cheung A. (2014). Nitric oxide regulation of adult neurogenesis. Vitam Horm 96, 59-77.
https://www.ncbi.nlm.nih.gov/pubmed/25189384

Helga Groll

Current role: Associate Features Editor, eLife Sciences Publications Ltd.

Thesis title: Host Location in a Specialist Parasitoid Wasp via Olfactory Cues - A Physiological, Behavioural and Morphological Study
https://eprints.soton.ac.uk/344256/1/final_final_Thesis_Helga_Groll.pdf

Wells T, Wolf S, Nicholls E, Groll H, Lim K-S, J Clark S, Swain J, Osborne J & Haughton A. (2016). Flight performance of actively foraging honey bees is reduced by a common pathogen, vol. 8.
https://www.researchgate.net/publication/304362601_Flight_performance_of_actively_foraging_honey_bees_is_reduced_by_a_common_pathogen

Groll H, Poppy G, L. Newland P, Roselino A & Giurfa M. (2009). 3Dimensional organisation of the antennal lobe of the parasitoid Cotesia plutella: A confocal microscopic study, vol. 153.
https://www.researchgate.net/publication/247128407_3Dimensional_organisation_of_the_antennal_lobe_of_the_parasitoid_Cotesia_plutella_A_confocal_microscopic_study

Giurfa M, Fabre E, Flaven-Pouchon J, Groll H, Oberwallner B, Vergoz V, Roussel E & Sandoz J-C. (2009). Olfactory conditioning of the sting extension reflex in honeybees: Memory dependence on trial number, interstimulus interval, intertrial interval, and protein synthesis, vol. 16.
https://www.researchgate.net/publication/40027230_Olfactory_conditioning_of_the_sting_extension_reflex_in_honeybees_Memory_dependence_on_trial_number_interstimulus_interval_intertrial_interval_and_protein_synthesis

Umar Sajjid

Thesis title: Regulation of the redox homeostasis during polygluatamine misfolding in Huntingtin's Disease
https://eprints.soton.ac.uk/168315/1/Umar%2527s_Thesis.pdf

Hands SL, Mason R, Sajjad MU, Giorgini F & Wyttenbach A. (2010). Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington's disease. Biochem Soc Trans 38, 552-558.
https://www.ncbi.nlm.nih.gov/pubmed/20298220

Neil Roberts

Current role: Kidney Research UK funded Research Fellow, investigating Urofacial Syndrome, Division of Cell Matrix Biology, University of Manchester

Thesis title: The role of SOX9 during human pancreas development

Pritchett J, Athwal V, Roberts N, Hanley NA & Hanley KP. (2011). Understanding the role of SOX9 in acquired diseases: lessons from development. Trends Mol Med 17, 166-174.
https://www.ncbi.nlm.nih.gov/pubmed/21237710

Stuart HM, Roberts NA, Burgu B, Daly SB, Urquhart JE, Bhaskar S, Dickerson JE, Mermerkaya M, Silay MS, Lewis MA, Olondriz MB, Gener B, Beetz C, Varga RE, Gulpinar O, Suer E, Soygur T, Ozcakar ZB, Yalcinkaya F, Kavaz A, Bulum B, Gucuk A, Yue WW, Erdogan F, Berry A, Hanley NA, McKenzie EA, Hilton EN, Woolf AS & Newman WG. (2013). LRIG2 mutations cause urofacial syndrome. Am J Hum Genet 92, 259-264.

https://www.ncbi.nlm.nih.gov/pubmed/23313374

Jennings RE, Berry AA, Kirkwood-Wilson R, Roberts NA, Hearn T, Salisbury RJ, Blaylock J, Piper Hanley K & Hanley NA. (2013). Development of the human pancreas from foregut to endocrine commitment. Diabetes 62, 3514-3522.
https://www.ncbi.nlm.nih.gov/pubmed/23630303

Priscilla Day

Current role: Postdoctoral Research, Dept of Physiology, Development and Neuroscience, University of Cambridge

Thesis title: The transfer and metabolism of glucose and amino acids by the human placenta
https://eprints.soton.ac.uk/377713

Cleal JK, Day P, Hanson MA & Lewis RM. (2009). Measurement of housekeeping genes in human placenta. Placenta 30, 1002-1003.
http://www.sciencedirect.com/science/article/pii/S0143400409002987?via%3Dihub

Cleal JK, Day PL, Hanson MA & Lewis RM. (2010). Sex differences in the mRNA levels of housekeeping genes in human placenta. Placenta 31, 556-557.
http://www.sciencedirect.com/science/article/pii/S0143400410001165?via%3Dihub

Cleal JK, Glazier JD, Ntani G, Crozier SR, Day PE, Harvey NC, Robinson SM, Cooper C, Godfrey KM, Hanson MA & Lewis RM. (2011). Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast. J Physiol 589, 987-997.
http://onlinelibrary.wiley.com/doi/10.1113/jphysiol.2010.198549/abstract

Day PE, Cleal Jk, Lofthouse Em, Hanson Ma & Lewis RM. (2013). What factors determine placental glucose transfer kinetics? Placenta 34, 953-958.
https://www.ncbi.nlm.nih.gov/pubmed/23886770

Day PEL, Cleal JK, Lofthouse EM, Goss V, Koster G, Postle A, Jackson JM, Hanson MA, Jackson AA & Lewis RM. (2013). Partitioning of glutamine synthesised by the isolated perfused human placenta between the maternal and fetal circulations. Placenta 34, 1223-1231.
https://www.ncbi.nlm.nih.gov/pubmed/24183194

Cleal JK, Day PE, Simner CL, Barton SJ, Mahon PA, Inskip HM, Godfrey KM, Hanson MA, Cooper C, Lewis RM, Harvey NC & Group SWSS. (2015). Placental amino acid transport may be regulated by maternal vitamin D and vitamin D-binding protein: results from the Southampton Women's Survey. Br J Nutr 113, 1903-1910.
https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/placental-amino-acid-transport-may-be-regulated-by-maternal-vitamin-d-and-vitamin-dbinding-protein-results-from-the-southampton-womens-survey/70734D650187428C6BBB7A61B1E8438A

Day PE, Ntani G, Crozier SR, Mahon PA, Inskip HM, Cooper C, Harvey NC, Godfrey KM, Hanson MA, Lewis RM & Cleal JK. (2015). Maternal Factors Are Associated with the Expression of Placental Genes Involved in Amino Acid Metabolism and Transport. PLoS One 10, e0143653.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143653

October 2008

Laura Roncoroni

Current role: Senior Clinical Manager at Novartis, Basel, Switzerland (as of 2018)

Thesis title: Functional role of the background potassium channel K2P15.1
https://eprints.soton.ac.uk/360274/

Mant A, Williams S, Roncoroni L, Lowry E, Johnson D & O'Kelly I. (2013). N-glycosylation-dependent control of functional expression of background potassium channels K2P3.1 and K2P9.1. J Biol Chem 288, 3251-3264.
http://www.jbc.org/content/288/5/3251

Mohinder Pal

Current role: Research Fellow, Genome Damage and Stability, University of Sussex (as of 2018)

Thesis title: Protein mis-folding and human disease https://eprints.soton.ac.uk/167063/

Pal M, Erskine PT, Gill RS, Wood SP & Cooper JB. (2010). Near-atomic resolution analysis of BipD, a component of the type III secretion system of Burkholderia pseudomallei. Acta Crystallogr Sect F Struct Biol Cryst Commun 66, 990-993.
https://www.ncbi.nlm.nih.gov/pubmed/20823511

Pal M, Morgan M, Phelps SE, Roe SM, Parry-Morris S, Downs JA, Polier S, Pearl LH & Prodromou C. (2014). Structural basis for phosphorylation-dependent recruitment of Tel2 to Hsp90 by Pih1. Structure 22, 805-818.
https://www.ncbi.nlm.nih.gov/pubmed/24794838

Olly Dewhirst

"Oliver is a postdoctoral researcher working on the LOCATE project at the University of Sussex. His research interests include gait classification of wild animals using data recorded from motion sensing collars and methods to identify group hunting strategies using GPS tracking data." (as of 2018)

Thesis title: Nonlinear System Analysis of Local Reflex Control of Locust Hind Limbs https://eprints.soton.ac.uk/351342/1/PhDODComp.pdf

Angarita-Jaimes N, Dewhirst OP, Simpson DM, Kondoh Y, Allen R & Newland PL. (2012). The dynamics of analogue signalling in local networks controlling limb movement. Eur J Neurosci 36, 3269-3282.
 http://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2012.08236.x/abstract?lipi=urn%3Ali%3Apage%3Ad_flagship3_profile_view_base%3BJSOInzqETp6cCHBt5QiV3Q%3D%3D

Dewhirst O, Simpson DM, Allen R, & Newland PL (2009)
Neuromuscular reflex control of limb movement - validating models of the locust's hind leg control system using physiological input signals,
IEEE EMBS 1.35: 689-692

Dewhirst OP, Simpson DM, Angarita R, Allen R, & Newland PL (2009)
Wiener-Hammerstein parameter estimation using differential evolution - application to limb reflex dynamics.
Biosignals ???, 271-276

Dewhirst OP, Simpson DM, Allen R, & Newland PL (2009).
Validating system identification models of the locusts hind leg reflex control loop using walking and sinusoidal inputs.
Abstracts of Eighth Gottingen Meeting of the German Neuroscience Society, Gottingen, 25-29th March

Dewhirst OP, Angarita-Jaimes N, Simpson DM, Allen R & Newland PL. (2013). A system identification analysis of neural adaptation dynamics and nonlinear responses in the local reflex control of locust hind limbs. J Comput Neurosci 34, 39-58.
https://link.springer.com/article/10.1007/s10827-012-0405-9?lipi=urn%3Ali%3Apage%3Ad_flagship3_profile_view_base%3BJSOInzqETp6cCHBt5QiV3Q%3D%3D

Dewhirst OP, Evans HK, Roskilly K, Harvey RJ, Hubel TY & Wilson AM. (2016). Improving the accuracy of estimates of animal path and travel distance using GPS drift-corrected dead reckoning. Ecol Evol 6, 6210-6222.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5016644/?lipi=urn%3Ali%3Apage%3Ad_flagship3_profile_view_base%3BJSOInzqETp6cCHBt5QiV3Q%3D%3D

Hubel TY, Myatt JP, Jordan NR, Dewhirst OP, McNutt JW & Wilson AM. (2016). Energy cost and return for hunting in African wild dogs and cheetahs. Nat Commun 7, 11034.
https://www.nature.com/articles/ncomms11034?lipi=urn%3Ali%3Apage%3Ad_flagship3_profile_view_base%3BJSOInzqETp6cCHBt5QiV3Q%3D%3D

Hubel TY, Myatt JP, Jordan NR, Dewhirst OP, McNutt JW & Wilson AM. (2016). Additive opportunistic capture explains group hunting benefits in African wild dogs. Nat Commun 7, 11033.
https://www.nature.com/articles/ncomms11033?lipi=urn%3Ali%3Apage%3Ad_flagship3_profile_view_base%3BJSOInzqETp6cCHBt5QiV3Q%3D%3D

Vidal-Gadea AG, Jing XJ, Simpson D, Dewhirst OP, Kondoh Y, Allen R & Newland PL. (2010). Coding characteristics of spiking local interneurons during imposed limb movements in the locust. J Neurophysiol 103, 603-615.
https://www.ncbi.nlm.nih.gov/pubmed/19955290

Sam Collins

Dr Samuel Collins completed a PhD at the University of Southampton studying bacterial biofilm formation and 3-dimensional structure. His first postdoctoral position was undertaken at the Environmental Health Care Unit at the University of Southampton where he participated in an EU FP7 drinking water decontamination project. In 2013 Sam joined the Biosafety Investigation Unit at Public Health England as a Microbiologist. Sam has undertaken several research projects in the area of water microbiology with a particular focus on diagnostic and detection methods. He has participated in several outbreak investigations related to Legionella and non-tuberculosis mycobacteria. Sam is also an on-call scientist for the Rare and Imported Pathogens Laboratory at PHE Porton responsible for diagnosing a wide range of unusual bacterial and viral pathogens. Sam deployed to Sierra Leone twice during the current Ebola outbreak to help establish and run the PHE diagnostic laboratories. (as of 2018)

Thesis title: The role of hypoxia and DNA mismatch repair in neuroblastoma multicellular tumour spheroid formation

Collins SL, Afshar B, Walker JT, Aird H, Naik F, Parry-Ford F, Phin N, Harrison TG, Chalker VJ, Sorrell S & Cresswell T. (2016). Heated birthing pools as a source of Legionnaires' disease. Epidemiol Infect 144, 796-802.
https://www.ncbi.nlm.nih.gov/pubmed/26289365

Collins S, Jorgensen F, Willis C & Walker J. (2015). Real-time PCR to supplement gold-standard culture-based detection of Legionella in environmental samples. J Appl Microbiol 119, 1158-1169.
https://www.ncbi.nlm.nih.gov/pubmed/26218315

Collins SL, Herve R, Keevil CW, Blaydes JP & Webb JS. (2011). Down-regulation of DNA mismatch repair enhances initiation and growth of neuroblastoma and brain tumour multicellular spheroids. PLoS One 6, e28123.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0028123

Conibear TC, Collins SL & Webb JS. (2009). Role of mutation in Pseudomonas aeruginosa biofilm development. PLoS One 4, e6289.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006289

Chand M, Lamagni T, Kranzer K, Hedge J, Moore G, Parks S, Collins S, Del Ojo Elias C, Ahmed N, Brown T, Smith EG, Hoffman P, Kirwan P, Mason B, Smith-Palmer A, Veal P, Lalor MK, Bennett A, Walker J, Yeap A, Isidro Carrion Martin A, Dolan G, Bhatt S, Skingsley A, Charlett A, Pearce D, Russell K, Kendall S, Klein AA, Robins S, Schelenz S, Newsholme W, Thomas S, Collyns T, Davies E, McMenamin J, Doherty L, Peto TE, Crook D, Zambon M & Phin N. (2017). Insidious Risk of Severe Mycobacterium chimaera Infection in Cardiac Surgery Patients. Clin Infect Dis 64, 335-342
https://academic.oup.com/cid/article/2631865/Insidious-risk-of-severe-Mycobacterium-chimaera?lipi=urn%3Ali%3Apage%3Ad_flagship3_profile_view_base%3B7ibXdb5eSgKtSowounFJ3A%3D%3D

Collins S, Stevenson D, Bennett A & Walker J. (2017). Occurrence of Legionella in UK household showers. Int J Hyg Environ Health 220, 401-406.
http://www.sciencedirect.com/science/article/pii/S1438463916305028

Collins SL, Stevenson D, Mentasti M, Shaw A, Johnson A, Crossley L & Willis C. (2017). High prevalence of Legionella in non-passenger merchant vessels. Epidemiol Infect 145, 647-655.
https://www.cambridge.org/core/journals/epidemiology-and-infection/article/high-prevalence-of-legionella-in-nonpassenger-merchant-vessels/3AF3E92E6942705E67B84C4284FADFB6

Mentasti M, Afshar B, Collins S, Walker J, Harrison TG & Chalker V. (2016). Rapid investigation of cases and clusters of Legionnaires' disease in England and Wales using direct molecular typing. J Med Microbiol 65, 484-493.
http://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.000257?lipi=urn%3Ali%3Apage%3Ad_flagship3_profile_view_base%3B7ibXdb5eSgKtSowounFJ3A%3D%3D#tab2

Nola Pickard (neé Adeosun)

Thesis title: Synthesis and cardioprotective activities of green tea polyphenols and their analogues
https://eprints.soton.ac.uk/362977/

Gale PA, Tong CC, Haynes CJ, Adeosun O, Gross DE, Karnas E, Sedenberg EM, Quesada R & Sessler JL. (2010). Octafluorocalix[4]pyrrole: a chloride/bicarbonate antiport agent. J Am Chem Soc 132, 3240-3241.
https://eprints.soton.ac.uk/144883/

October 2009

Kirstin Williamson

Thesis title: Evolutionary trade-offs with innate immune resistance; implications for ageing, oxidative stress resistance and motor function https://eprints.soton.ac.uk/363662/1/__soton.ac.uk_ude_PersonalFiles_Users_lp5_mydocuments_Theses%2520PDF%2520files_Kirstin%2520Williamson%2520-%2520Final%2520Doctoral%2520Thesis.pdf

Piia Keskiväli

Thesis title: Piia Keskiväli- Bond Effects of acute early age statin treatment on rat vasculature

 Pike KC, Davis SA, Collins SA, Lucas JSA, Inskip HM, Wilson SJ, Thomas ER, Wain HA, Keskivali-Bond PHM, Cooper C, Godfrey KM, Torrens C, Roberts G & Holloway JW. (2014). Prenatal development is linked to bronchial reactivity: epidemiological and animal model evidence. Sci Rep-Uk 4.
https://www.ncbi.nlm.nih.gov/pubmed/24740086

Rebecca Stead

Current role: NHS Clinical Scientist (as of 2018)

Thesis title: Novel Roles for the MAPK interacting serine threonine kinases (Mnks) https://eprints.soton.ac.uk/358973/1/__soton.ac.uk_ude_PersonalFiles_Users_lp5_mydocuments_Theses%2520PDF%2520files_Thesis%2520Rebecca%2520Stead.pdf

Stead RL & Proud CG. (2013). Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a). FEBS Lett 587, 2623-2628.
https://www.ncbi.nlm.nih.gov/pubmed/23831578

Moore CE, Pickford J, Cagampang FR, Stead RL, Tian S, Zhao X, Tang X, Byrne CD & Proud CG. (2016). MNK1 and MNK2 mediate adverse effects of high-fat feeding in distinct ways. Sci Rep 6, 23476.
https://www.ncbi.nlm.nih.gov/pubmed/27087055

Stead R, Musa MG, Bryant CL, Lanham SA, Johnston DA, Reynolds R, Torrens C, Fraser PA & Clough GF. (2016). Developmental conditioning of endothelium-derived hyperpolarizing factor-mediated vasorelaxation. J Hypertens 34, 452-463; discussion 463.
https://www.ncbi.nlm.nih.gov/pubmed/26682783

October 2010

Megan Sealey

Current role: Postdoctoral worker, Pharmacology, University of Oxford (as of 2018)

Thesis title: Investigating how ageing contributes to tauopathy: implications for Alzheimer's Disease (2016)
 https://eprints.soton.ac.uk/407490/

Sinadinos C, Quraishe S, Sealey M, Samson PB, Mudher A & Wyttenbach A. (2013). Low endogenous and chemical induced heat shock protein induction in a 0N3Rtau-expressing Drosophila larval model of Alzheimer's disease. J Alzheimers Dis 33, 1117-1133.
https://www.ncbi.nlm.nih.gov/pubmed/23114515

Newman T, Sinadinos C, Johnston A, Sealey M & Mudher A. (2011). Using Drosophila models of neurodegenerative diseases for drug discovery. Expert Opin Drug Dis 6, 129-140.
https://www.ncbi.nlm.nih.gov/pubmed/22647132

Sealey M, Vourkou E, M. Cowan C, Bossing T, Quraishe S, Grammenoudi S, Skoulakis E & Mudher A. (2017). Distinct phenotypes of three-repeat and four-repeat human tau in a transgenic model of tauopathy, vol. 105.
https://www.researchgate.net/publication/316871478_Distinct_phenotypes_of_three-repeat_and_four-repeat_human_tau_in_a_transgenic_model_of_tauopathy

Quraishe S, Sealey M, Cranfield L & Mudher A. (2016). Microtubule stabilising peptides rescue tau phenotypes in-vivo. Sci Rep 6, 38224.
https://www.nature.com/articles/srep38224

M Cowan C, Quraishe S, Hands S, Sealey M, Mahajan S, W Allan D & Mudher A. (2015). Rescue from tau-induced neuronal dysfunction produces insoluble tau oligomers, vol. 5.
https://www.researchgate.net/publication/284728473_Rescue_from_tau- induced_neuronal_dysfunction_produces_insoluble_tau_oligomers

Cowan CM, Sealey MA, Quraishe S, Targett MT, Marcellus K, Allan D & Mudher A. (2011). Modelling tauopathies in Drosophila: insights from the fruit fly. Int J Alzheimers Dis 2011, 598157.
https://www.hindawi.com/journals/ijad/2011/598157/cta/

Cowan C, Sealey M, Allan D & Mudher A. (2011). Which attributes of tau mediate toxicity: Phosphorylation or aggregation?, vol. 7.
https://www.researchgate.net/publication/241117234_Which_attributes_of_tau_mediate_toxicity_Phosphorylation_or_aggregation

Alison Yeomans (neé Donlevy)

Current role: Postdoctoral research, Cancer Studies, University of Southampton (as of 2018)

Thesis title: Regulation of RNA Translation by Phenethyl Isothiocyanate 
https://eprints.soton.ac.uk/362491/1/Ali%2520Yeomans%2520Thesis%2520December%25202013.pdf

Cavell BE, Alwi SSS, Donlevy A & Packham G. (2010). Anti-angiogenic effects of dietary isothiocyanates; mechanisms of action and implications for human health. Biochemical Pharmacology 81, 327.
https://hal.archives-ouvertes.fr/hal-00654981

Cavell BE, Syed Alwi SS, Donlevy AM, Proud CG & Packham G. (2012). Natural Product-Derived Antitumor Compound Phenethyl Isothiocyanate Inhibits mTORC1 Activity via TSC2. Journal of Natural Products 75, 1051-1057.
http://pubs.acs.org/doi/abs/10.1021/np300049b

Syed Alwi SS, Cavell BE, Donlevy A & Packham G. (2012). Differential induction of apoptosis in human breast cancer cell lines by phenethyl isothiocyanate, a glutathione depleting agent. Cell Stress & Chaperones 17, 529-538.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535168/

Aguilar-Hernandez MM, Blunt MD, Dobson R, Yeomans A, Thirdborough S, Larrayoz M, Smith LD, Linley A, Strefford JC, Davies A, Johnson PM, Savelyeva N, Cragg MS, Forconi F, Packham G, Stevenson FK & Steele AJ. (2016). IL-4 enhances expression and function of surface IgM in CLL cells. Blood 127, 3015-3025.
https://www.ncbi.nlm.nih.gov/pubmed/27002119

Yeomans A & Packham G. (2016). Shooting the messenger (RNA) in B-cell lymphoma. Blood 127, 794-796.
https://www.ncbi.nlm.nih.gov/pubmed/26893394

Yeomans A, Thirdborough SM, Valle-Argos B, Linley A, Krysov S, Hidalgo MS, Leonard E, Ishfaq M, Wagner SD, Willis AE, Steele AJ, Stevenson FK, Forconi F, Coldwell MJ & Packham G. (2016). Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation. Blood 127, 449-457.
https://www.ncbi.nlm.nih.gov/pubmed/26491071

Papadakis E, Robson N, Yeomans A, Bailey S, Laversin S, Beers S, Sayan AE, Ashton-Key M, Schwaiger S, Stuppner H, Troppmair J, Packham G & Cutress R. (2016). A combination of trastuzumab and BAG-1 inhibition synergistically targets HER2 positive breast cancer cells. Oncotarget 7, 18851-18864.
https://www.ncbi.nlm.nih.gov/pubmed/26958811

Yeomans A, Lemm E, Wilmore S, Cavell BE, Valle-Argos B, Krysov S, Hidalgo MS, Leonard E, Willis AE, Forconi F, Stevenson FK, Steele AJ, Coldwell MJ & Packham G. (2016). PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2alpha phosphorylation in established cell lines and primary human leukemia cells. Oncotarget 7, 74807-74819.
https://www.ncbi.nlm.nih.gov/pubmed/27579538

Charlotte Lawrence

Thesis title: Towards a small molecule inhibitor of the HIF-1?/HIF-1? protein-protein interaction
 https://eprints.soton.ac.uk/374783/

Miranda E, Nordgren IK, Male AL, Lawrence CE, Hoakwie F, Cuda F, Court W, Fox KR, Townsend PA, Packham GK, Eccles SA & Tavassoli A. (2013). A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells. J Am Chem Soc 135, 10418-10425.
https://www.ncbi.nlm.nih.gov/pubmed/23796364

Emma Lofthouse (neé Field)

Current role: Postdoctoral Research worker, Academic Unit of Human Development and Health, University of Southampton (as of 2018)

Thesis title: The accumulation of glutamate in the placental syncytiotrophoblast as a driver of membrane transport https://www.researchgate.net/publication/299465259_The_accumulation_of_glutamate_in_the_placental_syncytiotrophoblast_as_a_driver_of_membrane_transport?ev=prf_high

Lofthouse EM, Brooks S, Cleal JK, Hanson MA, Poore KR, O'Kelly IM & Lewis RM. (2015). Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast. J Physiol-London 593, 4549-4559.
https://www.ncbi.nlm.nih.gov/pubmed/26277985

Day PE, Cleal Jk, Lofthouse Em, Hanson Ma & Lewis RM. (2013). What factors determine placental glucose transfer kinetics? Placenta 34, 953-958.
https://www.ncbi.nlm.nih.gov/pubmed/23886770

Day PEL, Cleal JK, Lofthouse EM, Goss V, Koster G, Postle A, Jackson JM, Hanson MA, Jackson AA & Lewis RM. (2013). Partitioning of glutamine synthesised by the isolated perfused human placenta between the maternal and fetal circulations. Placenta 34, 1223-1231.
https://www.ncbi.nlm.nih.gov/pubmed/24183194

Lofthouse EM, Perazzolo S, Brooks S, Crocker IP, Glazier JD, Johnstone ED, Panitchob N, Sibley CP, Widdows KL, Sengers BG & Lewis RM. (2016). Phenylalanine transfer across the isolated perfused human placenta: an experimental and modeling investigation. Am J Physiol Regul Integr Comp Physiol 310, R828-836.
https://www.ncbi.nlm.nih.gov/pubmed/26676251

Palaiologou E, Goggin P, Chatelet DS, Lofthouse EM, Torrens C, Sengers BG, Cleal JK, Page A & Lewis RM. (2017). Serial block-face scanning electron microscopy of erythrocytes protruding through the human placental syncytiotrophoblast. J Anat 231, 634-637.
https://www.ncbi.nlm.nih.gov/pubmed/28714092

James Atherton

(Died 14/01/13) Awarded a posthumous PhD

Atherton JA, Holloway JA, Clough GF & Englyst NA (2011).
CD31 is not a marker for endothelial microparticles.
Poster British microcirculation annual conference 2011

Atherton JA, Hampshire TAH, Holloway JA, Clough GF, Englyst NA & Smith DC. (2012). The cardiopulmonary bypass pump is not responsible for alterations in platelet microparticle counts during cardiac surgery, vol. 225.
https://www.researchgate.net/publication/274029943

Atherton JA, Holloway JA, Smith DC, Clough GF & Englyst NA. (2012). Endothelial Microparticle Generation is Blood Vessel Specific, vol. 225.
https://www.researchgate.net/publication/274627911

Nancy Wong

Thesis title: Is there a conserved function for the GTG/GPHR family of membrane proteins?
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.632611

Raffaella Petruzelli

Thesis title: Role of environmental oxygen in the regulation of human embryonic stem cells

E. Forristal C, Christensen D, E. Chinnery F, Petruzzelli R, L. Parry K, Sanchez-Elsner T & Houghton F. (2013). Environmental Oxygen Tension Regulates the Energy Metabolism and Self-Renewal of Human Embryonic Stem Cells, vol. 8.
https://www.researchgate.net/publication/236684899_Environmental_Oxygen_Tension_Regulates_the_Energy_Metabolism_and_Self-Renewal_of_Human_Embryonic_Stem_Cells

Sarnelli G, Grosso M, Cirillo C, Palumbo I, Zaninotto G, Annese V, Rizzetto C, Latiano A, Savarese M, Petruzzelli R, Izzo P & D'Agostino E. (2010). OC.08.6 SIGNIFICANT ASSOCIATION OF LONGER FORMS OF CCTTT MICROSATELLITE REPEAT IN THE INDUCIBLE NITRIC OXIDE SYNTHASE PROMOTER WITH ACHALASIA, vol. 42.

https://www.researchgate.net/publication/245953857_OC086_SIGNIFICANT_ASSOCIATION_OF_LONGER_FORMS_OF_CCTTT_MICROSATELLITE_REPEAT_IN_THE_INDUCIBLE_NITRIC_OXIDE_SYNTHASE_PROMOTER_WITH_ACHALASIA

Sarnelli G, Grosso M, Cirillo C, Palumbo I, Rizzetto C, Zaninotto G, Latiano A, Annese V, Savarese M, Petruzzelli R, Izzo P & Sepulveres R. (2010). T1912 Association Between Ccttt Pentanucleotide Repeat in the Inducible Nitric Oxide Synthase Promoter Polymorphism and Achalasia, vol. 138.
https://www.researchgate.net/publication/246758016_T1912_Association_Between_Ccttt_Pentanucleotide_Repeat_in_the_Inducible_Nitric_Oxide_Synthase_Promoter_Polymorphism_and_Achalasia

Petruzzelli R, Christensen D, L Parry K, Sanchez-Elsner T & Houghton F. (2014). HIF-2a Regulates NANOG Expression in Human Embryonic Stem Cells following Hypoxia and Reoxygenation through the Interaction with an Oct-Sox Cis Regulatory Element, vol. 9.
https://www.researchgate.net/publication/266326740_HIF-2a_Regulates_NANOG_Expression_in_Human_Embryonic_Stem_Cells_following_Hypoxia_and_Reoxygenation_through_the_Interaction_with_an_Oct-Sox_Cis_Regulatory_Element

Sarnelli G, Grosso M, Palumbo I, Pesce M, Dalessandro A, Zaninotto G, Annese V, Petruzzelli R, Izzo P, Sepulveres R, Bruzzese D, Esposito G & Cuomo R. (2016). Allele-specific transcriptional activity of the variable number of tandem repeats of the inducible nitric oxide synthase gene is associated with idiopathic achalasia, vol. 5.
https://www.researchgate.net/publication/302922531_Allele-specific_transcriptional_activity_of_the_variable_number_of_tandem_repeats_of_the_inducible_nitric_oxide_synthase_gene_is_associated_with_idiopathic_achalasia

Sarah Louise Williams

Thesis title: Role for acid-sensitive two-pore domain (K_2P) potassium channels in cancer

Williams S, Bateman A & O'Kelly I. (2013). Altered Expression of Two-Pore Domain Potassium (K2P) Channels in Cancer, vol. 8.
https://www.researchgate.net/publication/257649976_Altered_Expression_of_Two-Pore_Domain_Potassium_K2P_Channels_in_Cancer

Mant A, Williams S & O'Kelly I. (2013). Acid sensitive background potassium channels K 2P 3.1 and K 2P 9.1 undergo rapid dynamin-dependent endocytosis, vol. 7.
https://www.researchgate.net/publication/242652899_Acid_sensitive_background_potassium_channels_K_2P_31_and_K_2P_91_undergo_rapid_dynamin-dependent_endocytosis

Mant A, Williams S, Roncoroni L, Lowry E, Johnson D & O'Kelly I. (2012). N-Glycosylation-dependent Control of Functional Expression of Background Potassium Channels K2P3.1 and K2P9.1.
https://www.researchgate.net/publication/233949414_N-Glycosylation-dependent_Control_of_Functional_Expression_of_Background_Potassium_Channels_K2P31_and_K2P91

October 2011

Andrew Hutton

Current role: Senior Scientist at GammaDelta Therapeutics in London (as of 2018)

Thesis title: Characterization of fibroblast T-cell interactions in the airways

Hutton AJ, Polak ME, Spalluto CM, Wallington JC, Pickard C, Staples KJ, Warner JA & Wilkinson TM. (2017). Human Lung Fibroblasts Present Bacterial Antigens to Autologous Lung Th Cells. J Immunol 198, 110-118.
https://www.ncbi.nlm.nih.gov/pubmed/27895174

Centlivre M, Petit M, Hutton AJ, Dufossee M, Boccara D, Mimoun M, Soria A & Combadiere B. (2017). Analysis of the skin of mice humanized for the immune system. Exp Dermatol 26, 963-966.
https://www.ncbi.nlm.nih.gov/pubmed/28267869

Katherine Stubbs

Thesis title: Investigating neurodegeneration in a Drosophila model of tauopathy https://eprints.soton.ac.uk/395374/1/Katy%2520Stubbs.Thesis%2520Corrected%2520Final%252023Mar2016.pdf

Christine Reitmeyer

Thesis title: Investigating the effects of diesel exhaust pollution on honey bee behaviour and neurobiology (not in eprints)

Bader MI, Reitmayer C, Arndt C, Wober J, Kretzschmar G, Zierau O & Vollmer G. (2012). Age dependency of estrogen responsiveness in the uterus and adipose tissue of aromatase-knockout (ArKO) mice. The Journal of steroid biochemistry and molecular biology 128, 29-37.

Pfennig F, Kurth T, Meissner S, Standke A, Hoppe M, Zieschang F, Reitmayer C, Gobel A, Kretzschmar G & Gutzeit HO. (2012). The social status of the male Nile tilapia (Oreochromis niloticus) influences testis structure and gene expression. Reproduction (Cambridge, England) 143, 71-84.

Claire Simner

Thesis title: Vitamin D transport and the effects on placental function and fetal growth (2015)
https://eprints.soton.ac.uk/386933/

James Schofield

Thesis title: Control of translation initiation and neuronal subcellular localisation of mRNAs by G-quadruplex structures
https://eprints.soton.ac.uk/397956/

Schofield JP, Cowan JL & Coldwell MJ. (2015). G-quadruplexes mediate local translation in neurons. Biochem Soc Trans 43, 338-342.
https://www.ncbi.nlm.nih.gov/pubmed/26009173

Bigler J, Boedigheimer M, Schofield JPR, Skipp PJ, Corfield J, Rowe A, Sousa AR, Timour M, Twehues L, Hu X, Roberts G, Welcher AA, Yu W, Lefaudeux D, Meulder B, Auffray C, Chung KF, Adcock IM, Sterk PJ, Djukanovic R & Group UBS. (2017). A Severe Asthma Disease Signature from Gene Expression Profiling of Peripheral Blood from U-BIOPRED Cohorts. Am J Respir Crit Care Med 195, 1311-1320.

https://www.ncbi.nlm.nih.gov/pubmed/27925796

Jessica Rajaram

Thesis title: The renin-angiotensin system enzymes in chronic obstructive pulmonary disease
https://eprints.soton.ac.uk/397328/

Louise Fairless

Thesis title: Ecology and Ecophysiology of Social Structure and Population Dynamics in Bats (Vespertilionidae) https://eprints.soton.ac.uk/360180/1/__soton.ac.uk_ude_PersonalFiles_Users_lp5_mydocuments_Theses%2520PDF%2520files_Louise%2520Fairless%2520Final%2520Thesis%252029%252010%252013.pdf

Mel Jannaway

Thesis title: The modulation of smooth muscle by contractility by specialised pro-resolving mediators

Meegan JEA-OhooX, Yang X, Coleman DC, Jannaway M & Yuan SY. (2017). Neutrophil-mediated vascular barrier injury: Role of neutrophil extracellular traps. LID - 10.1111/micc.12352 [doi]. Microcirculation.
https://www.ncbi.nlm.nih.gov/pubmed/28120468

Nicolas Dalliere

Thesis title: Delineation of a gut brain axis that regulates context-dependent feeding behaviour of the nematode Caenorhabditis elegans https://eprints.soton.ac.uk/388506/

Smus JP, Ludlow E, Dalliere N, Luedtke S, Monfort T, Lilley C, Urwin P, Walker RJ, O'Connor V, Holden-Dye L & Mahajan S. (2017). Coherent anti-Stokes Raman scattering (CARS) spectroscopy in Caenorhabditis elegans and Globodera pallida: evidence for an ivermectin-activated decrease in lipid stores. Pest Manag Sci.
http://onlinelibrary.wiley.com/doi/10.1002/ps.4707/full

Mouchiroud L, Molin L, Dalliere N & Solari F. (2010). Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging. Biofactors 36, 377-382.
http://onlinelibrary.wiley.com/doi/10.1111/j.1474-9726.2010.00640.x/full

Mouchiroud L, Molin L, Kasturi P, Triba MN, Dumas ME, Wilson MC, Halestrap AP, Roussel D, Masse I, Dalliere N, Segalat L, Billaud M & Solari F. (2011). Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans. Aging Cell 10, 39-54.
http://onlinelibrary.wiley.com/doi/10.1002/biof.127/full

October 2012

Przemyslaw Ociepa

Current role: Research Scientist at Green Fuels research, Bristol (as of 2018)

Thesis title: Investigating the role of pectin methylesterases in regulating root development in Arabidopsis thaliana
https://eprints.soton.ac.uk/405820/

Emily Farthing

Thesis title: Exploring the roles of membrane proteins in Manganese homeostasis of higher plants
 https://eprints.soton.ac.uk/405815/

Menguer PK, Farthing E, Peaston KA, Ricachenevsky FK, Fett JP & Williams LE. (2013). Functional analysis of the rice vacuolar zinc transporter OsMTP1. J Exp Bot 64, 2871-2883.
https://www.ncbi.nlm.nih.gov/pubmed/23761487

Girling RD, Lusebrink I, Farthing E, Newman TA & Poppy GM. (2013). Diesel exhaust rapidly degrades floral odours used by honeybees. Sci Rep-Uk 3.
https://www.ncbi.nlm.nih.gov/pubmed/24091789

Lusebrink I, Girling RD, Farthing E, Newman TA, Jackson CW & Poppy GM. (2015). The Effects of Diesel Exhaust Pollution on Floral Volatiles and the Consequences for Honey Bee Olfaction. J Chem Ecol 41, 904-912.
https://www.ncbi.nlm.nih.gov/pubmed/26424685

Farthing EC, Menguer PK, Fett JP & Williams LE. (2017). OsMTP11 is localised at the Golgi and contributes to Mn tolerance. Sci Rep 7, 15258.
https://www.nature.com/articles/s41598-017-15324-6

Gaia Andreoletti

Thesis title: Genomic analyses of paediatric inflammatory bowel disease (2016)
https://eprints.soton.ac.uk/403112/1/Cleaned%2520Andreoletti%2520resived%2520thesis%25201%25208%252016.pdf

Pengelly RJ, Gibson J, Andreoletti G, Collins A, Mattocks CJ & Ennis S. (2013). A SNP profiling panel for sample tracking in whole-exome sequencing studies.

https://www.ncbi.nlm.nih.gov/pubmed/24070238

Sophia Sander

Current role: University of Southampton · Centre for Human Development, Stem Cells and Regenerative Medicine

Thesis title: Role of microRNAs in the hypoxic regulation of human embryonic stem cells https://eprints.soton.ac.uk/434985/1/PhD_Thesis_SophiaSander_April2017_Final_Version_to_Submit.pdf

Presentations:

Effect of environmental oxygen on the expression of miRNAs in human embryonic stem cells

Sophia P Sander Tilman Sanchez-Elsner & Franchesca D Houghton

Society for Reproduction and Fertility Annual Conference 2015, Oxford, UK, 20 Jul 2015 - 22 Jul 2015

Role of miRNAs in the hypoxic regulation of human embryonic stem cells

Sophia P. Sander Tilman Sanchez-Elsner & Franchesca D. Houghton

Society for Reproduction and Fertility Annual Conference 2016, Winchester, UK, 11 Jul 2016 - 11 Jul 2016

October 2013

Alison Hill

Thesis title: Modelling the airway epithelial-mesenchymal trophic units in asthma (2016)

Hill AR, Donaldson JE, Blume C, Smithers N, Tezera L, Tariq K, Dennison P, Rupani H, Edwards MJ, Howarth PH, Grainge C, Davies DE & Swindle EJ. (2016). IL-1alpha mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit. Tissue Barriers 4, e1206378.

Alex Collcutt

Wu Z, Ni J, Liu Y, Teeling JL, Takayama F, Collcutt A, Ibbett P & Nakanishi H. (2017). Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice. Brain Behav Immun 65, 350-361.
https://www.ncbi.nlm.nih.gov/pubmed/?term=Collcutt%20A%5BAuthor%5D&cauthor=true&cauthor_uid=28610747

Chrysia Pegasiou

Vargas-Caballero M, Denk F, Wobst HJ, Arch E, Pegasiou CM, Oliver PL, Shipton OA, Paulsen O & Wade-Martins R. (2017). Wild-Type, but Not Mutant N296H, Human Tau Restores A beta-Mediated Inhibition of LTP in Tau(-/-) mice. Front Neurosci-Switz 11.
https://www.ncbi.nlm.nih.gov/pubmed/28484365

Cummings DM, Liu W, Portelius E, Bayram S, Yasvoina M, Ho SH, Smits H, Ali SS, Steinberg R, Pegasiou CM, James OT, Matarin M, Richardson JC, Zetterberg H, Blennow K, Hardy JA, Salih DA & Edwards FA. (2015). First effects of rising amyloid-beta in transgenic mouse brain: synaptic transmission and gene expression. Brain 138, 1992-2004.

https://www.ncbi.nlm.nih.gov/pubmed/25981962

Matthew Davies

Thesis title: Investigation of the unfolded protein response and other stress-related responses in distinct models of neurodegeneration (2016)
https://eprints.soton.ac.uk/390653/

Davies MJ, Cooper M, Perry VH & O'Connor V. (2015). Reduced expression of the presynaptic co-chaperone cysteine string protein alpha (CSPalpha) does not exacerbate experimentally-induced ME7 prion disease. Neurosci Lett 589, 138-143.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344215/

Juan Nunez

Current role: Head of Curriculum Design at Sololearn

Thesis title: Utilising high resolution imaging to interrogate blood vessel and bone cell interactions

https://eprints.soton.ac.uk/422899/1/Final_Thesis_JuanNunez.pdf

Papers
 Núñez JA, Goring A, Hesse E, Thurner PJ, Schneider P, Clarkin CE. (2017)
 Simultaneous visualisation of calcified bone microstructure and intracortical
 vasculature using synchrotron X-ray phase contrast-enhanced tomography.
 Scientific Reports.

https://www.nature.com/articles/s41598-017-13632-5

Núñez JA, Goring A, Javaheri B, Gomez-Nicola Diego, Hesse E, Pitsillides AA,
 Schneider P, Thurner PJ, Clarkin CE. (2017) Regional diversity in the murine cortical
 vascular network is revealed by synchrotron X-ray tomography and is reduced with
 age (2018). European Cells & Materials.

https://pubmed.ncbi.nlm.nih.gov/29790567/

Mosey H, Núñez JA, Goring A, Clarkin CE, Staines KA, Lee PD, Pitsillides AA, Javaheri B. (2017) Sost deficiency does not alter bone’s lacunar or vascular porosity.
 Frontiers in Materials.

https://www.frontiersin.org/articles/10.3389/fmats.2017.00027/full

Abstracts
Núñez JA, Goring A, Thurner PJ, Schneider P, Clarkin CE. Utilising high resolution
 imaging to interrogate blood vessel and bone cell interactions. Medical Engineering
 Centres Annual Meeting and Bioengineering 2014. Imperial College, London.

Núñez JA, Goring A, Hesse E, Thurner PJ, Schneider P, Clarkin CE. Identification of
 regional diversity in blood vessel structure within murine cortical bone. Bone
 Research Society Meeting 2016. University of Liverpool.

Núñez JA, Goring A, Hesse E, Thurner PJ, Schneider P, Clarkin CE. Age-related andsite-specific changes in the intracortical vascular network revealed by high-
 resolution synchrotron X-ray computed tomography, MEIBioeng16. University of
 Oxford.

Núñez JA, Goring A, Hesse E, Thurner PJ, Schneider P, Clarkin CE. Regional changes in cortical bone porosity in mice lacking vascular endothelial growth factor revealed by synchrotron X‐ray tomography. Poster presentation. Cell biology: osteoblasts and bone formation. ECTS 2017. Salzburg, Austria.

Núñez JA, Goring A, Hesse E, Thurner PJ, Schneider P, Clarkin CE. Simultaneous
 visualisation of calcified bone ultrastructure and intracortical vasculature using
 synchrotron X‐ray phase‐contrast tomography. ECTS 2017. Salzburg, Austria.

Awards:

Ann Stansfield Student Research Bursary from the Paget’s Association

https://www.southampton.ac.uk/life-sciences/news/2016/09/29-student-award.page

Jemma Paterson

Thesis title: Not just skin deep: circulating lipids in a “localised” disease and their role in angiogenesis

https://eprints.soton.ac.uk/449033/1/Jemma_Paterson_final_thesis.pdf

Publications:

Bottaro E, Paterson JAJ, Quercia L, Zhang X, Hill M, Patel VA, Jones SA, Lewis AL, Millar TM, Carugo D. In vitro and ex vivo evaluation of the biological performance of sclerosing foams. Sci Rep. 2019 Jul 8;9(1):9880. doi: 10.1038/s41598-019-46262-0. PMID: 31285447; PMCID: PMC6614483.

Bottaro E, Paterson J, Zhang X, Hill M, Patel VA, Jones SA, Lewis AL, Millar TM, Carugo D. Physical Vein Models to Quantify the Flow Performance of Sclerosing Foams. Front Bioeng Biotechnol. 2019 May 21;7:109. doi: 10.3389/fbioe.2019.00109. PMID: 31165068; PMCID: PMC6536569.

Lisa Jones

Current role: Press and Research Communications Manager · St George's, University of London

Thesis title: The Influence of early life vitamin D deficiency on offspring skeletal muscle development, structure and function.

https://eprints.soton.ac.uk/437657/1/Lisa_Ellen_Jones_PhD_Thesis_2018.pdf

Publications:

The effect of maternal and post-weaning high-fat diet on markers of skeletal muscle insulin-mediated glucose uptake and growth in adult mouse offspring. L. E. Jones, F. R. Cagampang1, K. Poore, J. K. Cleal, P. L. Newland, L. R. Green Proc Physiol Soc 37 · Jul 1, 2016

Jones, L., Markiewicz, F., James, R., Cagampang, F., Rustighi, E., Poore, K., Newland, P. and Green, L. (2015), Sex-specific Effects of Prenatal and Post-weaning High Fat Diet on Adult Mouse Offspring Skeletal Muscle Contraction. The FASEB Journal, 29: 123.5. https://doi.org/10.1096/fasebj.29.1_supplement.123.5

Talks:

Placental Homing Peptide-microRNA-145 Inhibitor Conjugates for Targeted Enhancement of Placenta Growth Reproductive Sciences · Mar 1, 2015

miR-145 is associated with placental growth in micemiR-145 is associated with placental growth in mice Endocrine Abstracts · Mar 1, 2014

Miguel Moreno Ramirez

Current role: Post-doctoral researcher in neuroscience at the University of Southampton

Thesis title: The small GTPase Rho1 couples peptidergic control of circadian behaviour to molecular oscillator function in Drosophila melanogaster

October 2014

Guilia Lioi

Lioi G, Bell SL & Simpson DM. (2016). Changes in Functional Brain Connectivity in the Transition from Wakefulness to Sleep in Different EEG Bands. In XIV Mediterranean Conference on Medical and Biological Engineering and Computing 2016: MEDICON 2016, March 31st-April 2nd 2016, Paphos, Cyprus, ed. Kyriacou E, Christofides S & Pattichis CS, pp. 3-8. Springer International Publishing, Cham.
https://link.springer.com/chapter/10.1007/978-3-319-32703-7_1

Prutha Patel

Magistri M, Velmeshev D, Makhmutova M, Patel P, Sartor GC, Volmar Ch, Wahlestedt C & Faghihi MA. (2016). The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease.
https://www.ncbi.nlm.nih.gov/pubmed/27117003

Alison Caldwell

Pye R, Hamede R, Siddle HV, Caldwell A, Knowles GW, Swift K, Kreiss A, Jones ME, Lyons AB & Woods GM. (2016). Demonstration of immune responses against devil facial tumour disease in wild Tasmanian devils. LID - 20160553 [pii] LID - 10.1098/rsbl.2016.0553 [doi].
https://www.ncbi.nlm.nih.gov/pubmed/28120799

Caldwell A & Siddle HV. (2017). The role of MHC genes in contagious cancer: the story of Tasmanian devils. Immunogenetics 69, 537-545.
https://www.ncbi.nlm.nih.gov/pubmed/28695294

Adam Dorey

Current role: Post-doctoral research fellow in nanotechnology at University College London

Thesis title: Arabidopsis and C.elegans GTG/GPHRs have a conserved role across kingdoms as anion channels

October 2015

Charlene Sibbons

Sibbons CM, Brenna JT, Lawrence P, Hoile SP, Clarke-Harris R, Lillycrop KA & Burdge GC. (2014). Effect of sex hormones on n-3 polyunsaturated fatty acid biosynthesis in HepG2 cells and in human primary hepatocytes. Prostaglandins Leukot Essent Fatty Acids 90, 47-54.

https://www.ncbi.nlm.nih.gov/pubmed/24411721

Hoile SP, Irvine NA, Kelsall CJ, Sibbons C, Feunteun A, Collister A, Torrens C, Calder PC, Hanson MA, Lillycrop KA & Burdge GC. (2013). Maternal fat intake in rats alters 20:4n-6 and 22:6n-3 status and the epigenetic regulation of Fads2 in offspring liver. J Nutr Biochem 24, 1213-1220.
https://www.ncbi.nlm.nih.gov/pubmed/23107313

Monika Kudelska

Kudelska MM, Holden-Dye L, O'Connor V & Doyle DA. (2017). Concentration-dependent effects of acute and chronic neonicotinoid exposure on the behaviour and development of the nematode Caenorhabditis elegans. Pest Manag Sci 73, 1345-1351.
https://www.ncbi.nlm.nih.gov/pubmed?term=Monika%20Kudelska%5BAuthor%5D

Natascha Vana

Vilotti S, Vana N, Van den Maagdenberg AM & Nistri A. (2016). Expression and function of calcitonin gene-related peptide (CGRP) receptors in trigeminal ganglia of R192Q Cacna1a knock-in mice. Neurosci Lett 620, 104-110.
https://www.ncbi.nlm.nih.gov/pubmed/27021026

Eleni Palaiologou

Palaiologou E, Goggin P, Chatelet DS, Lofthouse EM, Torrens C, Sengers BG, Cleal JK, Page A & Lewis RM. (2017). Serial block-face scanning electron microscopy of erythrocytes protruding through the human placental syncytiotrophoblast. J Anat 231, 634-637.

https://www.ncbi.nlm.nih.gov/pubmed?term=Eleni%20Palaiologou%5BAuthor%5D

Kerry Day (nee Gove)

Current role: Freelance scientific writer

Thesis: Understanding physiological and computed tomography measures of small airways disease and their clinical relevance in chronic obstructive pulmonary disease

Gove, K. Wilkinson, T. M. A., Jack, S., Ostridge, K., Thompson, B. and Conway, J. (2018). Systematic review of evidence for relationships between physiological and CT indices of small airways and clinical outcomes in COPD. Respir Med, 139, 10.1016/j.rmed.2018.05.005

Systematic review of evidence for relationships between physiological and CT indices of small airways and clinical outcomes in COPD - ScienceDirect

Ostridge, K., Gove, K., Paas, K., Burke, H., Freeman, A. T., Harden, S., Kirby, M., Peterson, S., Sieren, J., McCrae, C., Vaarala, O., Staples, K. J. and Wilkinson, T. M. A. (2019). Using novel computed tomography analysis to describe the contribution and distribution of emphysema and small airways disease in COPD. Ann Am Thorac, 16(8), 10.1513/AnnalsATS.201810-669OC

Using Novel Computed Tomography Analysis to Describe the Contribution and Distribution of Emphysema and Small Airways Disease in Chronic Obstructive Pulmonary Disease | Annals of the American Thoracic Society (atsjournals.org)

Charles Hurdle

Thesis: Light-induced plasticity of Drosophila central and peripheral circadian clock function  

Emilia Assar

Current role: Assistant Manager in Business Development at Public Health England

Thesis: The cellular mechanisms of autophagy during cell motility and focal adhesion turnover

Ryan, T. A., Phillips, E. O., Collier, C., Robinson, A. J. B., Routledge, D., Wood, R. E., Assar, E. A. and Tumbarello, D. A. (2020). Tollip coordinates Parkin-dependent trafficking of mitochondrial-derived vesicles. The EMBO Journal, 39(11), 10.15252/embj.2019102539

Tollip coordinates Parkin‐dependent trafficking of mitochondrial‐derived vesicles - PMC (nih.gov)

Assar, E. A. and Tumbarello, D. A. (2020). Loss of the essential autophagy regulators FIP200 or Atg5 leads to distinct effects on focal adhesion composition and organisation. Front Cell Dev Biol, 8, 10.3389/fcell.2020.00733

Frontiers | Loss of the Essential Autophagy Regulators FIP200 or Atg5 Leads to Distinct Effects on Focal Adhesion Composition and Organization (frontiersin.org)

Bradley Whitton

Current role: Senior scientist at Benevolent AI

Thesis: Investigating interactions between vacuolar ATPase proton pumps and androgen receptor signalling in prostate cancer

Whitton, B. Okamoto, H., Packham, G. and Crabb, S. (2018). Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer. Cancer Med, 7(8), 10.1002/cam4.1494

Vacuolar ATPase as a potential therapeutic target and mediator of treatment resistance in cancer - Whitton - 2018 - Cancer Medicine - Wiley Online Library

Whitton, B. Okamoto, H., Rose-Zerilli, M., Packham, G. and Crabb, S. J. (2021). V-ATPase inhibition decreases mutant androgen receptor activity in castrate-resistant prostate cancer. Mol Cancer Ther, 20(4), 10.1158/1535-7163.MCT-20-0662

V-ATPase Inhibition Decreases Mutant Androgen Receptor Activity in Castrate-resistant Prostate Cancer. - Abstract - Europe PMC

October 2016

Eleanor Seaby

Seaby EG & Gilbert RD. (2017). Thrombotic microangiopathy following haematopoietic stem cell transplant. LID - 10.1007/s00467-017-3803-4 [doi]. Pediatr Nephrol.
https://www.ncbi.nlm.nih.gov/pubmed/28993886

Seaby E, Bunyan D, Ennis S & D. Gilbert R. (2017). Sporadic, isolated Fanconi syndrome due to a mutation of EHHADH: a case report. Journal of Clinical Nephrology and Renal Care 3.
https://eprints.soton.ac.uk/413643/

Seaby E, D. Gilbert R, Andreoletti G, Pengelly R, Mercer C, Hunt D & Ennis S. (2017). Unexpected findings in a child with atypical HUS: an example of how genomics is changing the clinical diagnostic paradigm. Frontiers in Pediatrics 5.
https://www.ncbi.nlm.nih.gov/pubmed/28589114

Border S, Parton W, Myers M, Elmansouri A, Harrison C, Stephens J, Seaby E & Hall S. (2017). Ten considerations for implementing effective and sustainable near-peer teaching in clinical anatomy education. MedEdPublish 6.
https://www.mededpublish.org/manuscripts/1011

Andreoletti G, Seaby EG, Dewing JM, Kelly I, Lachlan K, Gilbert RD & Ennis S. (2017). AMMECR1: a single point mutation causes developmental delay, midface hypoplasia and elliptocytosis. Journal of Medical Genetics 54, 269.
http://jmg.bmj.com/content/54/4/269

Pengelly RJ, Arias L, Martínez J, Upstill-Goddard R, Seaby EG, Gibson J, Ennis S, Collins A & Briceño I. (2016). Deleterious coding variants in multi-case families with non-syndromic cleft lip and/or palate phenotypes. Sci Rep 6, 30457.
https://www.nature.com/articles/srep30457

Pengelly RJ, Greville-Heygate S, Schmidt S, Seaby EG, Jabalameli MR, Mehta SG, Parker MJ, Goudie D, Fagotto-Kaufmann C, Mercer C, Study DDD, Debant A, Ennis S & Baralle D. (2016). Mutations specific to the Rac-GEF domain of TRIO cause intellectual disability and microcephaly. J Med Genet.
http://jmg.bmj.com/content/early/2016/07/14/jmedgenet-2016-103942.full

Seaby EG, Gilbert RD, Pengelly RJ, Andreoletti G, Clarke A & Ennis S. (2016). Progressive myoclonic epilepsy with Fanconi syndrome. JRSM Open 7, 2054270415623145.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900196/

Connor Maltby

Current position: Post-doctoral research fellow at the University of Michigan Medical School

Thesis title: Regulation of translation and subcellular localisation of neuronal mRNAs by G-quadruplex structures

Maltby, C. J. Schofield, J. P. R., Houghton, S. D., O’Kelly, I., Vargas-Caballero, M., Deinhardt, K. and Coldwell, M. J. (2020). A 5’ UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation. Nucleic Acids Res, 48(17), 10.1093/nar/gkaa699

5′ UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation | Nucleic Acids Research | Oxford Academic (oup.com)

October 2017

Sebastien Pollet

Current position:

Occupational Therapist and Research Fellow based in Psychology at the University of Southampton

Thesis title: An investigation into cortical activity associated with robotic upper limb rehabilitation after stroke

https://eprints.soton.ac.uk/442937/1/Final_Thesis_2018_07_23.pdf

Poster presentations:

Published in the Journal of NeuroRehabilitation and Neural Repair June 2012; 26 (5) issue.

Pollet S, Burridge, J, and Conway, B (2012) Cortical activity changes among stroke patients following robotic upper limb rehabilitation as measured by EEG during reaching movements. In: 7th World Congress for NeuroRehabilitation (WCNR 2012), 16-19 May 2012, Melbourne, Australia.

Pollet S, Burridge, J, and Conway, B (2013) Development of a method to measure cortical activity changes associated with robotic upper limb rehabilitation after stroke. In: The Society for Research Rehabilitation (SRR) Winter Meeting, 5 February 2013, Bath, United Kingdom.

James Coates

Thesis title: Podiatric skin health sensing in the diabetic foot

https://eprints.soton.ac.uk/413767/1/FINAL_THESIS_J._Coates_PhD_Thesis.pdf

James Coates, Andrew Chipperfield and Geraldine Clough (2016) Wearable Multimodal Skin Sensing for the Diabetic Foot. Electronics. 2016 5(3):45 doi:10.3390/electronics5030045

https://www.mdpi.com/2079-9292/5/3/45

Giedo Elamin

Thesis title: The Role of Endothelial microvesicles In Thrombus Formation

Poster presentations:

Development of chandler loop for Examining thrombus formation at BSHT, aip & UK Platelet Group Annual Meeting 2016

Is activated protein c (apc) the missing link between endothelial microvesicles (emvs) and altered thrombus formation?

BSHT, aip & UK Platelet Group Annual Meeting 2017

Samah Zarroug

Current position: Senior Lecturer in Pharmacology at Alfaisal University, Saudi Arabia

Thesis title:Investigation of cue dependent feeding behaviour in Caenorhabditis

elegans reveals a critical mechanosensory dependent microcircuit in the

control of pharyngeal pumping

https://eprints.soton.ac.uk/434253/

Pooja Khurana

Current position: Marie Curie Alumni Association (MCAA) Editor,  Ambassador-Public Health The Pad Project

Thesis title: Mouse Embryonic Stem Cells as a Model System for Periconceptional

Developmental Programming

https://eprints.soton.ac.uk/427313/1/Pooja_Khurana_Final_PhD_Thesis_2018.pdf

Khurana, P., Smyth, N., Sheth, B., Velazquez, M., Eckert, J., & Fleming, T. (2022). Advanced maternal age perturbs mouse embryo development and alters the phenotype of derived embryonic stem cells. Journal of Developmental Origins of Health and Disease, 13(3), 395-405. doi:10.1017/S2040174421000325

https://www.cambridge.org/core/journals/journal-of-developmental-origins-of-health-and-disease/article/advanced-maternal-age-perturbs-mouse-embryo-development-and-alters-the-phenotype-of-derived-embryonic-stem-cells/8C3726A4A4BD49A9A9E3ACF03FF08C86

Khurana, P., Cox, A., Islam, B. et al. Maternal Undernutrition Induces Cell Signalling and Metabolic Dysfunction in Undifferentiated Mouse Embryonic Stem Cells. Stem Cell Rev and Rep (2022). https://doi.org/10.1007/s12015-022-10490-1

https://link.springer.com/article/10.1007/s12015-022-10490-1               

Fleming TP, Sun C, Denisenko O, Caetano L, Aljahdali A, Gould JM, Khurana P. Environmental Exposures around Conception: Developmental Pathways Leading to Lifetime Disease Risk. Int J Environ Res Public Health. 2021 Sep 6;18(17):9380. doi: 10.3390/ijerph18179380. PMID: 34501969; PMCID: PMC8431664.

https://pubmed.ncbi.nlm.nih.gov/34501969/

Talks:

Society for Reproduction and Fertility Annual Conference 2016, Winchester, UK,

Derivation and use of mouse embryonic stem cell lines as model for mechanistic analysis of periconceptional developmental programming, Pooja Khurana , Andy Cox , Tom Fleming & Neil Smyth

https://www.reproduction-abstracts.org/ra/0003/ra0003o017

Devon Lewis

Current position: CEO inulse

Thesis title: Naturalistic Fictive Locomotion with Real-time Joint Tracking and Closed Loop Proprioception

Winner of the University of Southampton’s innovation competition and runner up in EIBC national innovation competition:

https://www.southampton.ac.uk/news/2020/10/devon-lewis-inpulse-eibc.page

Charlotte Hill

Thesis title: Investigation into the Roles of Epithelial-Mesenchymal Transition (EMT) in Idiopathic Pulmonary Fibrosis (IPF)

 https://pure.soton.ac.uk/admin/files/88362173/Charlotte_Hill_FINAL_Thesis.pdf

Papers:

Hill, C and Wang Y. The importance of epithelial-mesenchymal transition and autophagy in cancer drug resistance. Cancer Drug Resistance 2019 Dec, (2578-532X)

https://pure.soton.ac.uk/admin/files/52568336/CDR_review.pdf

Chen, M., Zhou, Y., Xu, H. Hill, C et al. Bioinformatic analysis reveals the importance of epithelial-mesenchymal transition in the development of endometriosis. Sci Rep 10, 8442 (2020). https://doi.org/10.1038/s41598-020-65606-9

https://www.nature.com/articles/s41598-020-65606-9

Hill C, Jones MG, Davies DE, Wang Y. Epithelial-mesenchymal transition contributes to pulmonary fibrosis via aberrant epithelial/fibroblastic cross-talk. J Lung Health Dis. 2019 Apr 2;3(2):31-35. PMID: 31032489; PMCID: PMC6485666

https://pubmed.ncbi.nlm.nih.gov/31032489/

Wang Y, Xiong H, Liu D, Hill C, Ertay A, Li J, Zou Y, Miller P, White E, Downward J, Goldin RD, Yuan X, Lu X. Autophagy inhibition specifically promotes epithelial-mesenchymal transition and invasion in RAS-mutated cancer cells. Autophagy. 2019 May;15(5):886-899. doi: 10.1080/15548627.2019.1569912. Epub 2019 Feb 20. PMID: 30782064; PMCID: PMC6517269.

https://pubmed.ncbi.nlm.nih.gov/30782064/

Yuan Y, Li Y, Qiao G, Zhou Y, Xu Z, Hill C, Jiang Z, Wang Y. Hyperbaric Oxygen Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice. Front Mol Biosci. 2021 Jun 4;8:675437. doi: 10.3389/fmolb.2021.675437. PMID: 34150851; PMCID: PMC8211992.

https://pubmed.ncbi.nlm.nih.gov/34150851/

Yao L, Conforti F, Hill C, Bell J, Drawater L, Li J, Liu D, Xiong H, Alzetani A, Chee SJ, Marshall BG, Fletcher SV, Hancock D, Coldwell M, Yuan X, Ottensmeier CH, Downward J, Collins JE, Ewing RM, Richeldi L, Skipp P, Jones MG, Davies DE, Wang Y. Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis. Cell Death Differ. 2019 May;26(5):943-957. doi: 10.1038/s41418-018-0175-7. Epub 2018 Jul 26. PMID: 30050057; PMCID: PMC6252080.

https://pubmed.ncbi.nlm.nih.gov/30050057/

Liu, D., Ertay, A., Hill, C. et al. ASPP1 deficiency promotes epithelial-mesenchymal transition, invasion and metastasis in colorectal cancer. Cell Death Dis 11, 224 (2020). https://doi.org/10.1038/s41419-020-2415-2

https://www.nature.com/articles/s41419-020-2415-2#citeas

Yao S, Ertay A, Zhou Y, Yao L, Hill C, Chen J, Guan Y, Sun H, Ewing RM, Liu Y, Lv X, Wang Y. GRK6 Depletion Induces HIF Activity in Lung Adenocarcinoma. Front Oncol. 2021 May 31;11:654812. doi: 10.3389/fonc.2021.654812. PMID: 34136390; PMCID: PMC8201516.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201516/

Yuan Y, Zhou Y, Li Y, Hill C, Ewing RM, Jones MG, Davies DE, Jiang Z, Wang Y. Deconvolution of RNA-Seq Analysis of Hyperbaric Oxygen-Treated Mice Lungs Reveals Mesenchymal Cell Subtype Changes. Int J Mol Sci. 2020 Feb 18;21(4):1371. doi: 10.3390/ijms21041371. PMID: 32085618; PMCID: PMC7039706.

https://pubmed.ncbi.nlm.nih.gov/32085618/

Charlotte Hill Yihua Wang, Autophagy in pulmonary fibrosis: friend or foe?, Genes & Diseases,

Volume 9, Issue 6, 2022, Pages 1594-1607, ISSN 2352-3042,

https://doi.org/10.1016/j.gendis.2021.09.008.

https://www.sciencedirect.com/science/article/pii/S2352304221001161

Zhou Y, Hill C, Yao L, Li J, Hancock D, Downward J, Jones MG, Davies DE, Ewing RM, Skipp P, Wang Y. Quantitative Proteomic Analysis in Alveolar Type II Cells Reveals the Different Capacities of RAS and TGF-β to Induce Epithelial-Mesenchymal Transition. Front Mol Biosci. 2021 Mar 19;8:595712. doi: 10.3389/fmolb.2021.595712. PMID: 33869273; PMCID: PMC8048883.

https://www.frontiersin.org/articles/10.3389/fmolb.2021.595712/full

Ertay, A., Liu, H., Liu, D. Hill, C et al. Correction: WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer. Cell Death Dis 12, 269 (2021). https://doi.org/10.1038/s41419-021-03530-0

https://www.nature.com/articles/s41419-021-03530-0#citeas

Iytzia Castaneda-Davalos

Thesis title: Disentangling contribution of light and beneficial bacteria on the nutritional value of Brassica plants

Stephanie Robinson

Thesis title: 3-Dimensional Imaging and Mathematical Modelling of Human Pulmonary Lymphatics

https://eprints.soton.ac.uk/456052/1/S.K.Robinson_PhD_Bioengineering_Final_Thesis_Subm.pdf

Robinson, Stephanie K, Jonathan J Ramsden, Jane Warner, and Peter M Lackie. 2019. “Correlative
3D Imaging and Microfluidic Modelling of Human Pulmonary Lymphatics Using
Immunohistochemistry and High- Resolution μ CT.” Scientific Reports 9 (6415): 1–14.
https://doi.org/10.1038/s41598-019-42794-7.

https://www.nature.com/articles/s41598-019-42794-7

Basford, Philip J, Katsamenis, Orestis L., Boardman, Richard, Robinson, Stephanie, Konstantinopoulou, Elena, Gkoumas, Spyridon, Thuering, Thomas, Lackie, Peter, Cox, Simon and Schneider, Philipp (2021) Integration of a hybrid photon counting detector into a lab-based μCT scanner for 3D X-ray histology. ToScA UK & Europe 2021. 01 - 03 Sep 2021. 3 pp.

https://eprints.soton.ac.uk/451309/

Helena Rawsthorne

Current position: DSTL

Thesis title: C. elegans social behaviour as a functional approach to investigate the genetic determinants of autism spectrum disorder

 https://eprints.soton.ac.uk/452423/1/Helena_Rawsthorne_Manning_FINAL_PhD_Thesis.pdf

Rawsthorne, H., Calahorro, F., Feist, E., Holden-Dye, L., O’Connor, V. and Dillon, J. (2020) ‘Neuroligin dependence of social behaviour in C. elegans provides a model to investigate an autism associated gene’, Human Molecular Genetics, 29(21), pp. 3546-3553.

 https://pubmed.ncbi.nlm.nih.gov/33206170/

Rawsthorne, H., Calahorro, F., Holden-Dye, L., O’Connor, V. and Dillon, J. (2021) ‘Investigating autism associated genes in C. elegans reveals candidates with a role in social behaviour’, PLOS ONE, 16(5), pp. E0243121.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0243121

Rawsthorne-Manning, H., Calahorro F., Izquierdo P. G., Holden-Dye, L., O’Connor, V. and Dillon, J.(2021) ‘Confounds of using the unc-58 selection marker highlights the importance of genotyping co-CRISPR genes’, biorxiv, pp. 2021.05.26.44785.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0253351

Maria Fankhaenel

Current position: Postdoctoral Research Assistant · Barts Cancer Institute

Thesis title: Identification of Annexin A1 as a novel regulator of oriented cell divisions in mammary epithelial cells

https://eprints.soton.ac.uk/469101/1/PhD_Thesis_MariaFankhaenel_FINAL.pdf

Fankhaenel, M., Hashemi, F.S.G., Mourao, L. et al. Annexin A1 is a polarity cue that directs mitotic spindle orientation during mammalian epithelial morphogenesis. Nat Commun 14, 151 (2023).

https://doi.org/10.1038/s41467-023-35881-x

Monica Guerro-Carrasco

Project: Understanding the role of early-life inflammation on the incidence of Alzheimer's disease

Hu Y, Fryatt GL, Ghorbani M, Obst J, Menassa DA, Martin-Estebane M, Muntslag TAO, Olmos-Alonso A, Guerrero-Carrasco M, Thomas D, Cragg MS, Gomez-Nicola D. Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology. Cell Rep. 2021 Jun 8;35(10):109228. doi: 10.1016/j.celrep.2021.109228. PMID: 34107254; PMCID: PMC8206957.

https://pubmed.ncbi.nlm.nih.gov/34107254/

Evelin Szalai

Current position: Medical Writer at Fishawack Health

Thesis title: Physiological role of protein phosphatase 1 during chromosome segregation

Audett MR, Johnson EL, McGory JM, Barcelos DM, Szalai EO, Przewloka MR, Maresca TJ. The microtubule- and PP1-binding activities of Drosophila melanogaster Spc105 control the kinetics of SAC satisfaction. Mol Biol Cell. 2022 Jan 1;33(1):ar1. doi: 10.1091/mbc.E21-06-0307-T. Epub 2021 Oct 27. PMID: 34705493; PMCID: PMC8886820.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886820/

Jessica Bampton

Current position: Post doctoral research University of Southampton 

Thesis title: SOS for Plant Stress: The role of Singlet Oxygen Signalling in chloroplast development.

https://pure.soton.ac.uk/admin/editor/dk/atira/pure/api/shared/model/researchoutput/editor/thesiseditor.xhtml?scheme=&type=&id=109221755

Chapter in Book

The role of tetrapyrroles in chloroplast-to-nucleus retrograde signaling

Terry, M. J. & Bampton, J., 27 Jun 2019, (E-pub ahead of print) Metabolism, Structure and Function of Plant Tetrapyrroles: Control Mechanisms of Chlorophyll Biosynthesis and Analysis of Chlorophyll-Binding Proteins. Grimm, B. (ed.). Elsevier, Vol. 91. p. 225-246 (Advances in Botanical Research).

October 2018

Steve John

Thesis title:Chemical probes for precise dissection of the Wnt signalling pathway

Bowler-Barnett E, Martinez-Garcia FD, Sherwood M, Aleidan A, John S, Weston S, Wang Y, Divecha N, Skipp P, Ewing RM. Proteomic characterization of GSK3β knockout shows altered cell adhesion and metabolic pathway utilisation in colorectal cancer cells. PLoS One. 2021 Nov 5;16(11):e0246707. doi: 10.1371/journal.pone.0246707. PMID: 34739494; PMCID: PMC8570494.

https://pubmed.ncbi.nlm.nih.gov/34739494/

Lauren McNicholas

Current role: Clinical research assistant in ageing and movement research at the University of Bristol

Thesis title: The contribution of src family kinases to synaptic function and plasticity in adult wild-type mice and an inducible mouse model of Alzheimer’s disease.

Hannah Warming

Current role: Post-doctoral research scientist in neurodevelopment at the University of Oxford

Thesis title:  Haemoglobin neurotoxicity, haptoglobin scavenging and synaptic function in subarachnoid haemorrhage

Warming, H, K. Pegasiou, C., Pitera, A. P., Kariis, H., Houghton, S. D., Kurbatskaya, K., Ahmed, A., Grundy, P., Vajramani, G., Bulters, D., Altafaj, X., Deinhardt, K. and Vargas-Caballero, M. (2019). A primate-specific short GluN2A-NMDA receptor isoform is expressed in the human brain. Mol Brain, 12(1), 10.1186/s13041-019-0485-9

A primate-specific short GluN2A-N... preview & related info | Mendeley

Vargas-Caballero, M., Warming, H., Walker, R., Holmes, C., Cruickshank, G. and Patel, B. (2022). Vagus nerve stimulation as a potential therapy in early Alzheimer’s disease: a review. Front Hum Neurosci, 16, 10.3389/fnhum.2022.866434

Frontiers | Vagus Nerve Stimulation as a Potential Therapy in Early Alzheimer’s Disease: A Review (frontiersin.org)

Warming, H. Deinhardt, K., Garland, P., More, J., Bulters, D., Galea, I. and Vargas-Caballero, M. (2023). Functional effects of haemoglobin can be rescued by haptoglobin in an in vitro model of subarachnoid haemorrhage. BioRxiv, 10.1101/2023.01.25.525148

Functional effects of haemoglobin can be rescued by haptoglobin in an in vitro model of subarachnoid haemorrhage | bioRxiv

Dianne Lopez

Current role: Post-doctoral research scientist in neuroscience at the University of Southampton

Thesis title: Investigating the mechanisms of tau secretion across neuronal networks in health and disease

Hallinan, G. I., Lopez, D. M., Vargas-Caballero, M., West, J., Deinhardt, K. (2020). Co-culture of murine neurons using a microfluidic device for the study of Tau misfolding propagation. Bio-protoc, 10(16), 10.21769/BioProtoc.3718

Co-culture of Murine Neurons Using a Microfluidic Device for The Study of Tau Misfolding Propagation - PMC (nih.gov)

Rebecca Carter

Current role: Molecular biologist at Touchlight

Thesis title: The investigation of Zn homeostasis in the crop plant barley using CRISPR/Cas9 gene editing

Dawn Cooper

Current role Research fellow at the Drug Safety Research Unit

Thesis title: Investigating the effects of combined exposure to airborne house dust mite and particulate matter on bronchial epithelial cells

Cooper, D. M. and Loxham, M. (2019). Particulate matter and the airway epithelium: the special case of the underground? Eur Respir Rev, 28(153), 10.1183/16000617.0066-2019.

Particulate matter and the airway epithelium: the special case of the underground? - PMC (nih.gov)

Ben Bachelor

Current role: Product Specialist at ioLight Compact Microscopes

Thesis title: Developing a Drosophila based model in which to study aspects of pathological Tau transfer and seeding

Tania Garcia-Becerra

Current role: Imaging specialist at the Molecular Biology Institute of Barcelona (IBMB)

Thesis title: Molecular characterisation of rice GTG/GPHR reveals a conserved role as an anion channel that regulates endomembrane pH

October 2019

Laura Cooke

Cooke, L. D. F. Tumbarello, D. A., Harvey, N. C., Sethi, J. K., Lewis, R. M. and Cleal, J. K. (2021). Endocytosis in the placenta: an undervalued mediator of placental transfer. Placenta, 113, 10.1016/j.placenta.2021.04.014

Endocytosis in the placenta: An undervalued mediator of placental transfer - ScienceDirect

Ashley, B., Simner, C., Manousopoulou, A., Jenkinson, C., Hey, F., Frost, J. M., Rezwan, F. I., White, C. H., Lofthouse, E., Hyde, E., Cooke, L. D. F., Barton, S., Mahon, P. A., Curtis, E., Moon, R., Crozier, S., Inskip, H., Godfrey, K., Holloway, J., Cooper, C., Jones, K. S., Lewis, R., Hewison, M., Garbis, S., Branco, M. R., Harvey, N. and Cleal, J. K. (2022). Placental uptake and metabolism of 25(OH) vitamin D determines its activity within the fetoplacental unit. eLife, 11, 10.7554/eLife.71094

Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit | eLife (elifesciences.org)

Moon, R., Cooke, L. D. F., D'Angelo, S., Curtis, E., Titcombe, P., Davies, J., Godfrey, K., Cleal. J. K., Lewis, R., Cooper, C. and Harvey, N. (2022). Maternal and fetal genetic variation in vitamin D metabolism and umbilical cord blood 25-hydroxyvitamin D. J Clin Endocrinol Metab, 107(8), 10.1210/clinem/dgac263

Maternal and Fetal Genetic Variation in Vitamin D Metabolism and Umbilical Cord Blood 25-Hydroxyvitamin D | The Journal of Clinical Endocrinology & Metabolism | Oxford Academic (oup.com)

Woolford, S. J., Curtis, E. M., D'Angelo, S., Mahon, P., Cooke, L., Cleal, J. K., Crozier, S. R., Godfrey, K. M., Inskip, H. M., Cooper, C., & Harvey, N. C. (2020). Placental volume at 11 weeks is associated with offspring bone mass at birth and in later childhood: Findings from the Southampton Women's Survey. Placenta, 99, 10.1016/j.placenta.2020.07.017

Placental volume at 11 weeks is associated with offspring bone mass at birth and in later childhood: Findings from the Southampton Women's Survey - ScienceDirect

Lloyd Steele-Nicholson

Steele-Nicholson, L. J. and Andrews, M. R. (2022). Axon-targeting motifs: mechanisms and applications of enhancing axonal localisation of transmembrane proteins. Cells, 11(6), 10.3390/cells11060937

Cells | Free Full-Text | Axon-Targeting Motifs: Mechanisms and Applications of Enhancing Axonal Localisation of Transmembrane Proteins (mdpi.com)

Kathryn Hussey

Owen, R. S., Ramarathinam, S. H., Bailey, A., Gastaldello, A., Hussey, K., Skipp, P. J., Purcell, A. W. and Siddle, H. V. (2021). The differentiation state of the Schwann cell progenitor drives phenotypic variation between two contagious cancers. PLoS Pathog, 17(11), 10.1371/journal.ppat.1010033

The differentiation state of the Schwann cell progenitor drives phenotypic variation between two contagious cancers | PLOS Pathogens

Hussey, K. Caldwell, A., Kreiss, A., Skjødt, K., Gastaldello, A., Pye, R., Hamede, R., Woods, G, M. and Siddle, H. V. (2022). Expression of the nonclassical MHC Class I, Saha-UD in the transmissible cancer devil facial tumour disease (DFTD). Pathogens, 11(3), 10.3390/pathogens11030351

Pathogens | Free Full-Text | Expression of the Nonclassical MHC Class I, Saha-UD in the Transmissible Cancer Devil Facial Tumour Disease (DFTD) (mdpi.com)

Michael Price:

Project: Light-mediated switching of circadian pacemaker function across the neural clock circuit of Drosophila

Jacob Trend

Barker, C. T., Naish, D., Trend, J., Michels, L. V., Witmer, L., Ridgley, R., Rankin, K., Clarkin, C. E., Schneider, P. and Gostling, N. J. (2022). Modified skulls but conservative brains? The paleoneurology and endocranial anatomy of baryonychine dinosaurs (Theropoda: Spinosauridae). J Anat, 00, 10.1111/joa.13837

Modified skulls but conservative brains? The palaeoneurology and endocranial anatomy of baryonychine dinosaurs (Theropoda: Spinosauridae) - Barker - Journal of Anatomy - Wiley Online Library

Trend, J. Sharma, A., Michels, L., Goggin, P., Schneider, P., Deinhardt, K. and Clarkin, C. E. (2022). Regional assessment of male murine bone exposes spatial heterogeneity in osteocyte lacunar volume associated with intracortical canals and regulation by VEGF. BioRxiv, 10.1101/2023.02.08.527672

Regional assessment of male murine bone exposes spatial heterogeneity in osteocyte lacunar volume associated with intracortical canals and regulation by VEGF | bioRxiv

October 2020

Naomi Thorne

Thorne, N. J. and Tumbarello, D. A. (2022). The relationship of alpha-synuclein to mitochondrial dynamics and quality control. Front Mol Neurosci, 15, 10.3389/fnmol.2022.947191

Frontiers | The relationship of alpha-synuclein to mitochondrial dynamics and quality control (frontiersin.org)

Lucy Scullard

Aleksandra P Pitera, Iain J Hartnell, Lucy Scullard, Kirsten L Williamson, Delphine Boche, Vincent O'Connor, Katrin Deinhardt (2021) Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies. J Alzheimers Dis Rep, 5, 10.3233/ADR-210050

https://pubmed.ncbi.nlm.nih.gov/35088035/

Brad Richardson

Project: How do neurons age? Does this contribute to age-related decline in behaviour?

Ellie Seaby

Channon-Wells, S., Vito, O., McArdle, A. J., Seaby, E. G., Patel, H., Shah, P., & Lau, Y. L. (2023). Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study. Lancet Rheumatol. In press, 10.1016/S2665-9913(23)00035-8

Immunoglobulin, glucocorticoid, or combined therapy for multisystem inflammatory syndrome in children - ScienceDirect

Seaby, E. G. Thomas, S., Hunt, D., Baralle, D., Rehm, H. L., O’Donnell-Luria, A. L. and Ennis, S. (2023). A panel agnostic strategy “HiPPo” improves diagnostic efficiency in the UK Genome Medicine Service. MedRxiv, 10.1101/2023.01.31.23285025

A panel-agnostic strategy ‘HiPPo’ improves diagnostic efficiency in the UK Genome Medicine Service | medRxiv

Seaby, E. G. Thomas, N.S., Webb, A., Brittain, H., Taylor Tavares, A.L., Genomics England Consortium, Baralle, D., Rehm, H.L, O’Donnell-Luria, A., Ennis, S. (2023). Targeting de novo loss of function variants in constrained disease genes improves diagnostic rates in the 100,000 Genomes Project. Hum. Genet, 142, 10.1007/s00439-022-02509-x

Targeting de novo loss-of-function variants in constrained disease genes improves diagnostic rates in the 100,000 Genomes Project | SpringerLink

Seaby, E. G.,Turner, S., Bunyan, D.J., Seyed-Rezai, F., Essex, J., Gilbert, R.D. and Ennis, S. (2022), A novel variant in GATM causes idiopathic renal Fanconi syndrome and predicts progression to end-stage kidney disease. Clin. Genet, 103(2), 10.111/cge.14235

A novel variant in GATM causes idiopathic renal Fanconi syndrome and predicts progression to end‐stage kidney disease - Seaby - 2023 - Clinical Genetics - Wiley Online Library

Seaby, E. G., Baralle, D., Rehm, H. L., O’Donnell-Luria, A., & Ennis, S. (2022). Response to Ramos et al. Genet. Med, 24(12), 10.1016/j.gim.2022.08.016

Response to Ramos et al - ScienceDirect

Küry, S., Zhang, J., Besnard, T., Caro-Llopis, A., Zeng, X... Seaby, E. G. et al (2022). Rare pathogenic variants in WNK3 cause X-linked intellectual disability. Genet. Med, 24(9), 10.1016/j.gim.2022.05.009

Rare pathogenic variants in WNK3 cause X-linked intellectual disability - ScienceDirect

Ashton, J., Cheng, G., Stafford, I. S., Kellermann, M., Seaby, E. G., Fraser Cummings, J. R., Coelho, T., Batra, A., Afzal, N. A., Beattie, R. M. & Ennis, S. (2022). Prediction of Crohn’s disease stricturing phenotype using a NOD2-derived genomic biomarker. Inflamm. Bowel Dis, izac205, 10.1093/ibd/izac205

Prediction of Crohn’s Disease Stricturing Phenotype Using a NOD2-derived Genomic Biomarker | Inflammatory Bowel Diseases | Oxford Academic (oup.com)

Ashton, J. J., Seaby, E. G., Beattie, R. M., & Ennis, S. (2022). NOD2 in Crohn’s disease-unfinished business. J Crohns Colitis, jjac124, 10.1093/ecco-jcc/jjac124

NOD2 in Crohn’s Disease—Unfinished Business | Journal of Crohn's and Colitis | Oxford Academic (oup.com)

Janssen, B., van den Boogaard, M., Lichtenbelt, K., Seaby, E. G., Stals, K. et al. De novo putative Loss-of-function variants in TAF4 are associated with a neuro-developmental disorder. Hum Mutat, 43(12), 10.1002/humu.24444

De novo putative loss‐of‐function variants in TAF4 are associated with a neuro‐developmental disorder - Janssen - 2022 - Human Mutation - Wiley Online Library

Patel, H., McArdle, A., Seaby, E. G., Levin, M. and Whittaker, E. (2022). The immunopathogenesis of SARS-CoV-2 infection in children: diagnostics, treatment and prevention. Clin Transl Immunol, 11(7): e1405, 10.1002/cti2.1405

The immunopathogenesis of SARS‐CoV‐2 infection in children: diagnostics, treatment and prevention - PMC (nih.gov)

Melgar, M., Seaby, E. G., McArdle, A. J., Young, C. C., Campbell, A. P., Murray, N. L., Patel, M. M., Levin, M., Randolph, A. G., Son, M. B. F. and BATS Consortium and the Overcoming COVID‐19 Investigators. (2022). Treatment of Multisystem Inflammatory Syndrome in Children: Understanding Differences in Results of Comparative Effectiveness Studies. ACR Open Rheumatol, 4(9), 10.1002/acr2.11478

Treatment of Multisystem Inflammatory Syndrome in Children: Understanding Differences in Results of Comparative Effectiveness Studies - PMC (nih.gov)

Seaby, E. G. Smedley, D., Taylor Tavares, A.L., Brittain, H., van Jaarsveld, R.H., Baralle, D., Rehm, H.L., O’Donnell-Luria, A., Ennis, S. A gene-to-patient approaches uplifts novel disease gene discovery and identifies 18 putative novel disease genes. (2022). Genet. Med, 24(8), 10.1016/j.gim.2022.04.019

A gene-to-patient approach uplifts novel disease gene discovery and identifies 18 putative novel disease genes - ScienceDirect

Chen, S., Francioli, L., Goodrich, J., Collins, R., Wang, Q... Seaby, E. G. et al. (2022). A genome-wide mutational constraint map quantified from variation in 76,156 human genomes. BioRxiv. 10.1101/2022.03.20.485034

A genome-wide mutational constraint map quantified from variation in 76,156 human genomes | bioRxiv

Laricchia, K. M., Lake, N. J., Watts, N. A., Shand, M., Haessly, A... Seaby, E. G. et al. (2022). Mitochondrial DNA variation across 56,434 individuals in gnomAD. Genome Res, 32(3), 10.1101/gr.276013.121

Mitochondrial DNA variation across 56,434 individuals in gnomAD - PMC (nih.gov)

Gudmundsson, S., Singer-Berk, M., Watts, N., Phu, W., Goodrich, J. K., Solomonson, M., Genome Aggregation Database Consortium (inc. Seaby, E. G.), Rehm, H. L., MacArthur, D. G. and O’Donnell-Luria, A. (2022). Variant interpretation using population databases: lessons from gnomAD. Hum Mutat, 43(8), 10.1002/humu.24309

Variant interpretation using population databases: Lessons from gnomAD - PMC (nih.gov)

100,000 Genomes Project Pilot Investigators (inc. Seaby, E. G.). (2021). The 100,000 Genomes Pilot on rare disease diagnosis in healthcare preliminary report. N Engl J Med, 385(20), 10.1056/NEJMoa2035790

100,000 Genomes Pilot on Rare-Disease Diagnosis in Health Care — Preliminary Report - PMC (nih.gov)

Sirvent, S., Vallejo, A. F., Corden, E., Teo, Y., Davies, J., Clayton, K., Seaby, E. G., Lai, C., Ennis, S., Alyami, R., et al. (2021). TNFα signalling in the cutaneous immune network instructs local th17 allergen-specific inflammatory responses in atopic dermatitis. MedRxiv, 10.1101/2021/10.07.21264714

TNFα SIGNALLING IN THE CUTANEOUS IMMUNE NETWORK INSTRUCTS LOCAL Th17 ALLERGEN-SPECIFIC INFLAMMATORY RESPONSES IN ATOPIC DERMATITIS | medRxiv

Gudmundsson, S., Karczewski, K.J., Francioli, L.C., Tiao, G., Cummings, B. B... Seaby, E. G. et al. (2021). Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans. Nature, 597, 10.1038/s41586-021-03758-y1

Addendum: The mutational constraint spectrum quantified from variation in 141,456 humans | Nature

McArdle, A. J., Vito, O., Patel, H., Seaby, E. G., Shah, P., Wilson, C., Broderick, C., Nijman, R., Tremoulet, A. H., Munblit, D. et al (2021). Treatment of Multisystem Inflammatory Syndrome in Children. N Engl J Med, 385(1), 10.1056/NEJMoa2102968

Treatment of Multisystem Inflammatory Syndrome in Children - PMC (nih.gov)

Seaby, E. G. Rehm, H. L., & O'Donnell-Luria, A. (2021). Strategies to uplift novel Mendelian gene discovery for improved clinical outcomes. Front. Genet, 12, 10.3389/fgene.2021.674295

Frontiers | Strategies to Uplift Novel Mendelian Gene Discovery for Improved Clinical Outcomes (frontiersin.org)

Hoggart, C., Shimizu, C., Galassini, R., Wright, V. J., Shailes, H... Seaby, E. G. et al (2021). Identification of novel locus associated with coronary artery aneurysms and validation of loci for susceptibility to Kawasaki disease. Eur J Hum Genet, 29(12), 10.1038/s41431-021-00838-5

Identification of novel locus associated with coronary artery aneurysms and validation of loci for susceptibility to Kawasaki disease | European Journal of Human Genetics (nature.com)

Weng, P. L., Majmundar, A. J., Khan, K., Lim, T. Y., Shril, S... Seaby, E. G. et al (2021). De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis. Am J Hum Genet, 108(2), 10.1016/j.ajhg.2021.01.008

De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis - PMC (nih.gov)

Cummings, B. B., Karczewski, K. J., Kosmicki, J. A., Seaby, E. G., Watts, N. A. et al (2020). Transcript expression-aware annotation improves rare variant interpretation. Nature, 581, 10.1038/s41586-020-2329-2.

Transcript expression-aware annotation improves rare variant interpretation | Nature

Karczewski, K. J., Francioli, L. C., Tiao, G., Cummings, B. B., Alföldi, J... Seaby, E. G. et al. (2020). The mutational constraint spectrum quantified from variation in 141,456 humans. Nature, 581, 10.1038/s41586-020-2308-7

The mutational constraint spectrum quantified from variation in 141,456 humans | Nature

Seaby, E. G. and Ennis, S. (2020). Challenges in the diagnosis and discovery of rare genetic disorders using contemporary sequencing technologies. Brief Funct Genomics, 19(4), 10.1093/bfgp/elaa009

Challenges in the diagnosis and discovery of rare genetic disorders using contemporary sequencing technologies | Briefings in Functional Genomics | Oxford Academic (oup.com)

Wai, H. A., Lord, J., Lyon, M. Gunning, A., Kelly, H... Seaby, E. G. et al. (2020). Blood RNA analysis can increase clinical diagnostic rate and resolve variants of uncertain significance. Genet. Med, 22(6), 10.1038/s41436-020-0766-9

Blood RNA analysis can increase clinical diagnostic rate and resolve variants of uncertain significance - ScienceDirect

Beck, D. B., Petracovici, A., He, C., Moore, H. W., Louie, R. J... Seaby, E. et al. (2019). Delineation of the First Human Mendelian Disorder of the DNA Demethylation Machinery: TET3 Deficiency. Am J Hum Genet, 106(2), 10.1016/j.ajhg.2019.12.007

Delineation of a Human Mendelian Disorder of the DNA Demethylation Machinery: TET3 Deficiency - ScienceDirect

October 2021

Amber Cooper

Project: The identification of modifiers of trans-synaptic propagation of tau pathology in Drosophila

Christina Georgiadou

Project: The role of FcRIIb in Parkinson's Disease

October 2022

Joshua Green Jenkinson

Project: Investigating the regulatory role of central carbon metabolism on cell fate decisions during liver development and regeneration

Stephanie Turner

Project: Induction of lysosomal biogenesis in the retinal pigment epithelium (RPE) as a novel treatment for Stargardt disease

James Lamb

Project: Towards understanding autism – a pipeline to identify genetic variations contributing to autism spectrum disorders and dissect their mechanism of action

Daisy Bown

Project: Understanding the physiology of the Green Revolution to enhance wheat varieties for future food security